HealthDay

Combo Regimens Effective for Tx of Metastatic Renal Cell Cancer

WEDNESDAY, Feb. 20, 2019 (Pharmacist's Briefing) -- For first-line therapy of metastatic renal cell carcinoma, pembrolizumab plus axitinib and avelumab plus axitinib both show improved survival versus sunitinib, according to two studies published online Feb. 16 in the New England Journal of Medicine to coincide with the American Society of Clinical Oncology annual Genitourinary Cancers Symposium, held from Feb. 14 to 16 in San Francisco
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Prenatal Fluconazole Exposure Increases Neonatal Risks

WEDNESDAY, Feb. 20, 2019 (Pharmacist's Briefing) -- Maternal exposure to fluconazole during pregnancy may increase the risk for spontaneous abortion, according to a study published online Feb. 19 in CMAJ, the journal of the Canadian Medical Association
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Plazomicin Noninferior to Meropenem for Complicated UTI

WEDNESDAY, Feb. 20, 2019 (Pharmacist's Briefing) -- Plazomicin is noninferior to meropenem for patients with complicated urinary tract infections (UTIs), according to a study and a research letter published in the Feb. 21 issue of the New England Journal of Medicine
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HealthDay

Low Vitamin D Tied to High Blood Glucose Levels in Women

TUESDAY, Feb. 19, 2019 (Pharmacist's Briefing) -- Lower serum 25-hydroxyvitamin D (25[OH]D) concentrations appear to be associated with high blood glucose levels in women, according to a study recently published online in Menopause
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Darolutamide Slows Spread of Castration-Resistant Prostate Cancer

TUESDAY, Feb. 19, 2019 (Pharmacist's Briefing) -- Metastasis-free survival is significantly longer among men with nonmetastatic, castration-resistant prostate cancer treated with darolutamide versus placebo, according to a phase 3 study published online Feb. 14 in the New England Journal of Medicine to coincide with the American Society of Clinical Oncology annual Genitourinary Cancers Symposium, held from Feb. 14 to 16 in San Francisco
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Fewer Older Men Assessed, Treated for Osteoporosis

FRIDAY, Feb. 15, 2019 (Pharmacist's Briefing) -- Fewer older men than women undergo evaluation for or management of osteoporosis, according to a study published online Feb. 12 in the Journal of Investigative Medicine
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Rates of Osteonecrosis of the Jaw Low for Denosumab-Treated Women

THURSDAY, Feb. 14, 2019 (Pharmacist's Briefing) -- For denosumab-treated women with postmenopausal osteoporosis, invasive oral procedures and events (OPEs), including dental implants, tooth extraction, natural tooth loss, scaling/root planning, and jaw surgery, are common and associated with osteonecrosis of the jaw (ONJ), although the overall rate of ONJ is low, according to a study published online Feb. 13 in the Journal of Clinical Endocrinology & Metabolism
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CDC: Severity of Influenza Season Low Through Feb. 2, 2019

THURSDAY, Feb. 14, 2019 (Pharmacist's Briefing) -- The 2018 to 2019 influenza season has been low in severity so far, and overall vaccine effectiveness is about 47 percent, according to two reports published in the Feb. 15 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report
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HealthDay

FDA Panel Backs Ketamine-Like Drug for Depression

WEDNESDAY, Feb. 13, 2019 (Pharmacist's Briefing) -- An expert panel for the U.S. Food and Drug Administration has endorsed a drug for major depressive disorder that is a close relative to ketamine
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HealthDay

Guidelines Updated for Pulmonary Arterial Hypertension in Adults

WEDNESDAY, Feb. 13, 2019 (Pharmacist's Briefing) -- In the latest evidence-based guideline from the American College of Chest Physicians, published online Jan. 17 in CHEST, updated recommendations are provided for the management of adults with pulmonary arterial hypertension (PAH)
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HealthDay

Aspirin Underused for Advanced Colorectal Polyps

TUESDAY, Feb. 12, 2019 (Pharmacist's Briefing) -- Aspirin is underused to reduce the risk for colorectal cancer among patients with advanced colorectal polyps, according to a study recently published in The American Journal of Medicine
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HealthDay

Direct-Acting Antivirals Cut Mortality in Chronic Hepatitis C

TUESDAY, Feb. 12, 2019 (Pharmacist's Briefing) -- For adults with chronic hepatitis C virus (HCV) infection, direct-acting antivirals are associated with a reduced risk for mortality and hepatocellular carcinoma, according to a study published online Feb. 11 in The Lancet
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HealthDay

ASA: Reversal Agent Cuts Severe Bleeding With Factor Xa Inhibitors

MONDAY, Feb. 11, 2019 (Pharmacist's Briefing) -- The reversal agent, andexanet alfa, effectively reduces life-threatening bleeding in patients treated with factor Xa inhibitors, according to a study published online Feb. 7 in the New England Journal of Medicine to coincide with the American Stroke Association International Stroke Conference, held from Feb. 6 to 8 in Honolulu
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HealthDay

Certain Opioids Less Effective With SSRI Antidepressants

FRIDAY, Feb. 8, 2019 (Pharmacist's Briefing) -- Certain opioids are less effective for postoperative pain in patients taking selective serotonin reuptake inhibitor (SSRI) antidepressants, according to a study published online Feb. 6 in PLOS ONE
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HealthDay

High-Risk HPV Infection Linked to Increased Risk for CVD in Women

FRIDAY, Feb. 8, 2019 (Pharmacist's Briefing) -- High-risk human papillomavirus (HPV) infection is associated with an increased risk for developing cardiovascular disease (CVD), according to a study published online Feb. 7 in Circulation Research
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HealthDay

Trazodone Not Associated With Reduced Risk for Dementia

THURSDAY, Feb. 7, 2019 (Pharmacist's Briefing) -- Trazodone is not associated with a reduced risk for dementia compared with other antidepressants at the prodromal stage of disease, according to a study published online Feb. 5 in PLOS Medicine
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Drug Combo Tolerated in Younger Children With Cystic Fibrosis

THURSDAY, Feb. 7, 2019 (Pharmacist's Briefing) -- Lumacaftor/ivacaftor treatment is generally safe and well tolerated for children aged 2 to 5 years with cystic fibrosis (CF) homozygous for the F508del-CFTR mutation, according to a study published online Jan. 24 in The Lancet Respiratory Medicine
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HealthDay

ERAS Protocol Can Cut Opioid Use After Spine Surgery

WEDNESDAY, Feb. 6, 2019 (Pharmacist's Briefing) -- Implementation of a novel enhanced recovery after surgery (ERAS) protocol can reduce patients' postoperative opioid requirements after elective spinal or peripheral nerve surgery, according to a study recently published in the Journal of Neurosurgery
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Psoriasis Tx Linked to Drop in Noncalcified Coronary Plaque

WEDNESDAY, Feb. 6, 2019 (Pharmacist's Briefing) -- Treatment of psoriasis with biologic therapy is associated with a reduction in noncalcified coronary plaque and improved plaque morphology, according to a study published online Feb. 5 in Cardiovascular Research
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Omadacycline Noninferior to Moxifloxacin for Pneumonia

WEDNESDAY, Feb. 6, 2019 (Pharmacist's Briefing) -- Omadacycline is noninferior to moxifloxacin for community-acquired bacterial pneumonia and noninferior to linezolid for acute bacterial skin infections, according to two studies published in the Feb. 7 issue of the New England Journal of Medicine
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HealthDay

AAP Releases 2019 Childhood Immunization Schedules

TUESDAY, Feb. 5, 2019 (Pharmacist's Briefing) -- The 2019 recommended childhood and adolescent immunization schedules have been issued by the American Academy of Pediatrics and published online Feb. 5 in Pediatrics
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HealthDay

Texas Hospital Releases Quality Metrics for Opioid Stewardship Program

TUESDAY, Feb. 5, 2019 (Pharmacist's Briefing) -- Houston Methodist Hospital has established a set of quality metrics to help track and evaluate the use of opioids in the emergency department and the hospital overall
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HealthDay

Washington State Measles Cases Now at 48 Since Jan. 1

MONDAY, Feb. 4, 2019 (Pharmacist's Briefing) -- There have been 48 confirmed cases of measles in Washington state since the start of the year as health officials struggle to stop the spread of the infectious disease
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HealthDay

CDC Examines Safety of Recombinant Zoster Vaccine

MONDAY, Feb. 4, 2019 (Pharmacist's Briefing) -- During the first eight months of recombinant zoster vaccine (RZV) use, there were reports of 4,381 adverse events, 3 percent of which were serious, according to research published in the Feb. 1 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report
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American Geriatrics Society Releases Updated Beers Criteria for Appropriate Medication Use

MONDAY, Feb. 4, 2019 (Pharmacist's Briefing) The American Geriatrics Society has updated its medication reference tool, known as the Beers Criteria, commonly used by health care professionals to identify medications to avoid or to use with caution in older patients.
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HealthDay

Tofacitinib Benefits Sustained for Two Years in Patients With RA

MONDAY, Feb. 4, 2019 (Pharmacist's Briefing) -- The clinical benefits of tofacitinib in combination with methotrexate are sustained over two years among patients with rheumatoid arthritis (RA), according to a study published online Jan. 22 in Arthritis & Rheumatology
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HPV Educational Video May Increase Vaccination Rates

FRIDAY, Feb. 1, 2019 (Pharmacist's Briefing) -- Educational videos in pediatric clinics can increase rates of human papillomavirus (HPV) vaccination among adolescents, according to a study published in the January issue of Pediatrics
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Longitudinal TNF Levels Mainly Stable With Adalimumab in RA

FRIDAY, Feb. 1, 2019 (Pharmacist's Briefing) -- For patients with rheumatoid arthritis (RA), longitudinal tumor necrosis factor (TNF) concentrations are mainly stable during adalimumab treatment, although early low TNF is strongly linked to nonresponse to treatment, according to a study published in the Jan. 30 issue of Science Translational Medicine
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Oral Antibiotics Noninferior to IV for Bone, Joint Infection

THURSDAY, Jan. 31, 2019 (Pharmacist's Briefing) -- For patients being treated for bone or joint infection, oral antibiotics are noninferior to intravenous antibiotics, according to a study published in the Jan. 31 issue of the New England Journal of Medicine
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Small Increase in HbA1c Seen With Switch to Human Insulin in T2DM

THURSDAY, Jan. 31, 2019 (Pharmacist's Briefing) -- Switching from analogue to human insulin is associated with a small increase in hemoglobin A1c (HbA1c) levels, according to a study published in the Jan. 29 issue of the Journal of the American Medical Association
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