HealthDay

Higher LDL-C Levels Linked to Early-Onset Alzheimer Disease

FRIDAY, May 31, 2019 (Pharmacist's Briefing) -- Low-density lipoprotein (LDL) cholesterol is associated with the probability of developing early-onset Alzheimer disease (EOAD), according to a study published online May 28 in JAMA Neurology
Read More

HealthDay

Exercise, Therapy May Improve Depression, Diabetes Outcomes

FRIDAY, May 31, 2019 (Pharmacist's Briefing) -- Exercise and/or behavioral treatment interventions may provide clinically meaningful improvements in depression outcomes in adults with type 2 diabetes (T2DM) and major depressive disorder (MDD), according to a study published online May 21 in Diabetes Care
Read More

HealthDay

Noncompliance Common in Teens Prescribed STI Treatment in ED

FRIDAY, May 31, 2019 (Pharmacist's Briefing) -- Less than 60 percent of prescriptions for the treatment of sexually transmitted infections (STIs) among teens seeking care in the emergency department are filled, according to a research letter published online May 28 in JAMA Pediatrics
Read More

HealthDay

Esketamine Nasal Spray May Improve Refractory Depression Outcomes

FRIDAY, May 31, 2019 (Pharmacist's Briefing) -- Esketamine nasal spray plus an oral antidepressant appears to be a safe and effective treatment for patients with treatment-resistant depression, according to a study published online May 21 in The American Journal of Psychiatry
Read More

HealthDay

Ibrutinib, Venetoclax Active in High-Risk, Seniors With CLL

THURSDAY, May 30, 2019 (Pharmacist's Briefing) -- For high-risk and older patients with previously untreated chronic lymphocytic leukemia (CLL), the combination of ibrutinib and venetoclax is an active regimen, according to a study published in the May 30 issue of the New England Journal of Medicine
Read More

HealthDay

More Than 1 in 4 Middle-Aged Men, Women Have Low Bone Mineral Density

WEDNESDAY, May 29, 2019 (Pharmacist's Briefing) -- More than 25 percent of men and women aged 35 to 50 years have low bone mineral density (BMD), according to a study published in the June issue of the Journal of the American Osteopathic Association
Read More

HealthDay

Antiplatelets Do Not Up Recurrence in Intracerebral Hemorrhage

TUESDAY, May 28, 2019 (Pharmacist's Briefing) -- For patients with intracerebral hemorrhage, those who start antiplatelet therapy do not have an increased risk for recurrence, including those with cerebral microbleeds, according to two studies published online May 22 in The Lancet and The Lancet Neurology
Read More

HealthDay

Suboptimal BP, Fasting Glucose Tied to Atrioventricular Block

TUESDAY, May 28, 2019 (Pharmacist's Briefing) -- Suboptimal blood pressure and fasting glucose levels are associated with atrioventricular (AV) block, according to a study published online May 24 in JAMA Network Open
Read More

HealthDay

Statin Use With Colorectal Cancer Lowers Risk for Early Death

FRIDAY, May 24, 2019 (Pharmacist's Briefing) -- Use of statins before or after colorectal cancer (CRC) diagnosis is linked to a lower risk for premature death, from either cancer or other causes, according to a review published online May 8 in Cancer Medicine
Read More

HealthDay

Intracranial Hemorrhage Risk Up With Low-Dose Aspirin

FRIDAY, May 24, 2019 (Pharmacist's Briefing) -- For individuals without symptomatic cardiovascular disease, the use of low-dose aspirin for primary prevention of cardiovascular events is associated with an increased risk for intracranial hemorrhage, according to a review and meta-analysis published online May 13 in JAMA Neurology
Read More

HealthDay

Poor Glycemic Control Linked to Sarcopenia in T2DM

FRIDAY, May 24, 2019 (Pharmacist's Briefing) -- For patients with type 2 diabetes, poor glycemic control is associated with sarcopenia, according to a study published online May 9 in the Journal of Diabetes Investigation
Read More

HealthDay

Blood Donor Screening Data IDs Familial Hypercholesterolemia

THURSDAY, May 23, 2019 (Pharmacist's Briefing) -- Data from a blood donor screening program could represent a novel strategy for identifying familial hypercholesterolemia (FH), according to a study published online May 22 in JAMA Cardiology
Read More

HealthDay

Classification System Developed for Cardiogenic Shock

THURSDAY, May 23, 2019 (Pharmacist's Briefing) -- A classification system has been developed for categorizing cardiogenic shock; the consensus statement, endorsed by the American College of Cardiology, American Heart Association, Society of Critical Care Medicine, and Society of Thoracic Surgeons, was published online May 19 in Catheterization & Cardiovascular Interventions
Read More

HealthDay

Early cART Leads to Enhanced T Cell Function in HIV Infection

THURSDAY, May 23, 2019 (Pharmacist's Briefing) -- Early combination antiretroviral therapy (cART) leads to persistent functional T cell responses in most individuals with hyperacute HIV-1 infection, according to a study published online May 22 in Science Translational Medicine
Read More

HealthDay

Vitamin D Deficiency Tied to Gestational Diabetes Risk

WEDNESDAY, May 22, 2019 (Pharmacist's Briefing) -- Maternal vitamin D deficiency, as early as the first trimester of pregnancy, is associated with an increased risk for gestational diabetes mellitus (GDM), according to a study recently published in Diabetes, Obesity and Metabolism
Read More

HealthDay

Statin Use Reduces Dementia Risk After Concussion in Seniors

TUESDAY, May 21, 2019 (Pharmacist's Briefing) -- Older adults have an increased risk for dementia after concussion, which is modestly reduced among patients using a statin, according to a study published online May 20 in JAMA Neurology
Read More

HealthDay

Dupilumab Cuts Exacerbations in Late-Onset Asthma

TUESDAY, May 21, 2019 (Pharmacist's Briefing) -- Dupilumab is associated with significantly reduced severe exacerbation rates in patients with late-onset asthma with or without fixed airway obstruction, according to a study presented at the American Thoracic Society 2019 International Conference, held from May 17 to 22 in Dallas
Read More

HealthDay

Mometasone, Tiotropium Do Not Top Placebo in Mild Asthma

MONDAY, May 20, 2019 (Pharmacist's Briefing) -- For patients with mild asthma with a low sputum eosinophil level, outcomes do not differ significantly for mometasone or tiotropium versus placebo; and budesonide-formoterol is superior to albuterol for prevention of asthma exacerbations, according to two studies published online May 19 in the New England Journal of Medicine. The research was published to coincide with the American Thoracic Society 2019 International Conference, held from May 17 to 22 in Dallas
Read More

HealthDay

Early Neuromuscular Blockade No Better in ARDS Patients on Vent

MONDAY, May 20, 2019 (Pharmacist's Briefing) -- For patients with moderate-to-severe acute respiratory distress syndrome (ARDS) receiving mechanical ventilation, there is no difference in mortality between those receiving continuous infusion of cisatracurium and those receiving an approach with lighter sedation targets, according to a study published online May 19 in the New England Journal of Medicine. The research was published to coincide with the American Thoracic Society 2019 International Conference, held from May 17 to 22 in Dallas
Read More

HealthDay

Hormone Therapy in Transgender Women Ups Breast Cancer Risk

MONDAY, May 20, 2019 (Pharmacist's Briefing) -- Transgender women receiving hormone treatments are at greater risk for developing breast cancer than cisgender men, according to a study published online May 15 in The BMJ
Read More

HealthDay

Colorectal Cancer Incidence Increasing in Younger Adults

FRIDAY, May 17, 2019 (Pharmacist's Briefing) -- Colorectal cancer incidence is increasing among young adults in certain high-income countries, according to a study published online May 16 in The Lancet Gastroenterology & Hepatology
Read More

HealthDay

Dabigatran Does Not Beat Aspirin for Preventing Recurrent Stroke

THURSDAY, May 16, 2019 (Pharmacist's Briefing) -- Dabigatran is not superior to aspirin for preventing recurrent stroke in patients with recent history of embolic stroke of undetermined source, according to a study published in the May 16 issue of the New England Journal of Medicine
Read More

HealthDay

Risk for Miscarriage Up With Benzodiazepine Use in Early Pregnancy

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- The risk for spontaneous abortion (SA) is increased among early pregnancies with incident exposure to benzodiazepines, according to a study published online May 15 in JAMA Psychiatry
Read More

HealthDay

Habitual Glucosamine Use Linked to Reduced Risk for CVD Events

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- Habitual use of glucosamine supplements is associated with a reduced risk for cardiovascular disease (CVD) events, according to a study published online May 14 in The BMJ
Read More

HealthDay

Risk for Prolonged Opioid Use Up in Patients Receiving Tramadol

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- Receipt of tramadol alone after surgery is associated with an increased risk for prolonged opioid use, similar to that seen with other short-acting opioids, according to a study published online May 14 in The BMJ
Read More

HealthDay

Prophylactic Antibiotic Cuts Infection Risk After Operative Vaginal Birth

TUESDAY, May 14, 2019 (Pharmacist's Briefing) -- A single dose of a prophylactic antibiotic is beneficial after operative vaginal birth and reduces the risk for confirmed or suspected maternal infection, according to a study published online May 13 in The Lancet
Read More

HealthDay

Oral BTK Inhibitor Superior to Placebo in Multiple Sclerosis

TUESDAY, May 14, 2019 (Pharmacist's Briefing) -- The selective Bruton's tyrosine kinase (BTK) inhibitor evobrutinib at a dose of 75 mg once daily is associated with fewer enhancing lesions during weeks 12 through 24 among patients with relapsing multiple sclerosis, according to a study published May 10 in the New England Journal of Medicine to coincide with the annual meeting of the American Academy of Neurology, held from May 4 to 10 in Philadelphia
Read More

HealthDay

Infection Risk Lower With Certain Psoriasis Treatments

MONDAY, May 13, 2019 (Pharmacist's Briefing) -- For patients with psoriasis treated with systemic medications, the risk for serious infection is reduced for new users of apremilast, etanercept, and ustekinumab versus methotrexate, according to a study published online May 10 in JAMA Dermatology
Read More

HealthDay

Fournier Gangrene Is Safety Concern With SGLT2 Inhibitors

MONDAY, May 13, 2019 (Pharmacist's Briefing) -- Fournier gangrene (FG) is a safety concern for adults with diabetes receiving treatment with sodium-glucose cotransporter-2 (SGLT2) inhibitors, according to a study published online May 7 in the Annals of Internal Medicine
Read More

HealthDay

Eculizumab Reduces Risk for Relapse in Neuromyelitis Optica

FRIDAY, May 10, 2019 (Pharmacist's Briefing) -- For patients with aquaporin-4-immunoglobulin G-positive neuromyelitis optica spectrum disorder (NMOSD), eculizumab is associated with a lower risk for relapse, according to a study published online May 3 in the New England Journal of Medicine to coincide with the annual meeting of the American Academy of Neurology, held from May 4 to 10 in Philadelphia
Read More