HealthDay

Three Factors Predict Psych Events With Drugs for Smoking Cessation

THURSDAY, March 21, 2019 (Pharmacist's Briefing) -- Three factors predict clinically significant neuropsychiatric adverse events (NPSAEs) in smokers with or without mental health conditions who use cessation pharmacotherapy, according to a study published online March 7 in the Journal of General Internal Medicine
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Antibiotics, PPIs Tied to Higher C. Diff Risk in Hospitalized Children

THURSDAY, March 21, 2019 (Pharmacist's Briefing) -- Previous antibiotic exposure and use of proton pump inhibitors (PPIs) may be risk factors for Clostridioides (formerly Clostridium) difficile infection (CDI) in hospitalized pediatric patients, according to a review published online March 7 in Infection Control & Hospital Epidemiology
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In Youth With ADHD, New-Onset Psychosis Up With Amphetamines

THURSDAY, March 21, 2019 (Pharmacist's Briefing) -- For adolescents and young adults with attention-deficit/hyperactivity disorder (ADHD), new-onset psychosis occurs more often with amphetamine use versus methylphenidate use, according to a study published in the March 21 issue of the New England Journal of Medicine
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Daily Cannabis Use May Up Risk for Developing Psychotic Disorder

WEDNESDAY, March 20, 2019 (Pharmacist's Briefing) -- Cannabis use is associated with increased odds of psychotic disorder, according to a study published online March 19 in The Lancet Psychiatry
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Antiepileptic Drugs Not Tied to Dementia Risk

WEDNESDAY, March 20, 2019 (Pharmacist's Briefing) -- Antiepileptic drug (AED) use is not significantly associated with dementia risk in patients in Germany, according to a study published online March 12 in the Journal of Alzheimer's Disease
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FDA OKs Tecentriq for Extensive-Stage Small Cell Lung Cancer

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- Tecentriq (atezolizumab) has been approved by the U.S. Food and Drug Administration to treat adults with extensive-stage small cell lung cancer
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Analgesics in Pregnancy Do Not Seem to Cause Offspring Asthma

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- Analgesics taken during pregnancy, including opioids, antimigraine drugs, and paracetamol, do not appear to cause asthma, according to a study published online March 17 in the European Respiratory Journal
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Testosterone Replacement Slows Prostate Cancer Recurrence

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- For patients with localized prostate cancer, testosterone replacement therapy (TRT) slows recurrence, according to a study presented at the annual meeting of the European Association of Urology, held from March 15 to 19 in Barcelona, Spain
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Favorable Outcomes Seen in Long Term for ALLR3 Trial

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- For children with B-cell precursor acute lymphoblastic leukemia with late bone marrow relapse, risk stratification by minimal residual disease seems to be an effective strategy for treatment, according to a study recently published in The Lancet Haematology
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Dietary Cholesterol Ups Cardiovascular Disease Risk

MONDAY, March 18, 2019 (Pharmacist's Briefing) -- Higher consumption of dietary cholesterol, including eggs, is significantly associated with a higher risk for incident cardiovascular disease (CVD) and all-cause mortality, according to a study published in the March 19 issue of the Journal of the American Medical Association. This cardiovascular medicine theme issue was released early to coincide with the annual meeting of the American College of Cardiology, held from March 16 to 18 in New Orleans
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Antibacterial Envelope Can Reduce CIED Infections

MONDAY, March 18, 2019 (Pharmacist's Briefing) -- An antibacterial envelope can reduce the incidence of major cardiac implantable electronic device (CIED) infections, according to a study published online March 17 in the New England Journal of Medicine to coincide with the annual meeting of the American College of Cardiology, held from March 16 to 18 in New Orleans
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Supplement Use Low in Patients With Osteoporosis, Hip Fracture

FRIDAY, March 15, 2019 (Pharmacist's Briefing) -- Of patients diagnosed with osteoporosis who have a history of hip fracture, only 14 percent are receiving appropriate calcium and vitamin D supplementation, according to a study presented at the annual meeting of the American Academy of Orthopaedic Surgeons, held from March 12 to 16 in Las Vegas
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HealthDay

Guidelines Developed for Polymyxin Antibiotic Use

FRIDAY, March 15, 2019 (Pharmacist's Briefing) -- Recommendations have been developed for use of polymyxins, focusing on polymyxin B and polymyxin E (colistin); the guidelines were recently published in Pharmacotherapy
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Complex Dosing, Polypharmacy Common With Interstitial Lung Disease

THURSDAY, March 14, 2019 (Pharmacist's Briefing) -- Polypharmacy and complex medication regimens are common in patients with interstitial lung disease (ILD), according to a study published online Feb. 20 in Respirology
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Prenatal High-Dose Vitamin D Not Linked to Asthma at Age 6

THURSDAY, March 14, 2019 (Pharmacist's Briefing) -- High-dose vitamin D supplementation in pregnancy is not associated with a child's risk for asthma at age 6 years, according to a research letter published in the March 12 issue of the Journal of the American Medical Association
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HealthDay

One-Month Regimen Noninferior for Preventing HIV-Related TB

THURSDAY, March 14, 2019 (Pharmacist's Briefing) -- For HIV-infected patients, a one-month regimen of rifapentine and isoniazid is noninferior to nine months of isoniazid alone for preventing tuberculosis, according to a study published in the March 14 issue of the New England Journal of Medicine
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Short Regimen Noninferior for Rifampin-Resistant Tuberculosis

WEDNESDAY, March 13, 2019 (Pharmacist's Briefing) -- A short regimen is noninferior to a long regimen for patients with rifampin-resistant tuberculosis that is susceptible to fluoroquinolones and aminoglycosides, according to a study published online March 13 in the New England Journal of Medicine
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CDC: Most Americans Report Excellent, Good Health

WEDNESDAY, March 13, 2019 (Pharmacist's Briefing) -- Most Americans report having excellent or good health and have a usual place to go for medical care, according to a report published March 13 for the National Health Interview Survey Early Release Program
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HealthDay

Adding Bempedoic Acid to Statin Therapy Reduces LDL Cholesterol

WEDNESDAY, March 13, 2019 (Pharmacist's Briefing) -- Bempedoic acid, an inhibitor of ATP citrate lyase (ACLY), added to maximally tolerated statin therapy, significantly reduces levels of low-density lipoprotein (LDL) cholesterol in patients with atherosclerotic cardiovascular disease and/or heterozygous familial hypercholesterolemia, according to a study published in the March 14 issue of the New England Journal of Medicine
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HealthDay

Elderly Men Undertreated for Osteoporosis

WEDNESDAY, March 13, 2019 (Pharmacist's Briefing) -- Elderly men are significantly undertreated for osteoporosis, according to a study published online March 5 in the Journal of Pharmaceutical Health Services Research
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HealthDay

Four-to-Seven-Day Opioid Rx Likely Sufficient for Acute Pain Treatment

TUESDAY, March 12, 2019 (Pharmacist's Briefing) -- An opioid supply for seven or fewer days might be sufficient for most patients seen in primary care settings for acute pain who appear to need opioid analgesics, according to research published in the Feb. 15 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report
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Common Signs, Symptoms Do Not ID Dehydration in Seniors

TUESDAY, March 12, 2019 (Pharmacist's Briefing) -- Many older care home residents are not being diagnosed with dehydration based on commonly-used signs and symptoms, according to a study published online March 11 in the Journal of Post-Acute and Long-Term Care Medicine
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Probiotic Sanitation Cuts Antimicrobial Resistance in Hospitals

THURSDAY, March 7, 2019 (Pharmacist's Briefing) -- An environmental intervention of probiotic sanitation can effectively alter hospital microbiota, helping to limit the spread of antimicrobial resistance (AMR) in health care-associated infections (HAIs), according to a study published online Feb. 27 in Infection and Drug Resistance
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Hospital-Onset MRSA Decreased From 2002 to 2015

WEDNESDAY, March 6, 2019 (Pharmacist's Briefing) -- Staphylococcus aureus infections are still a concern in the United States, despite a decline seen in hospital-onset methicillin-resistant S. aureus (MRSA) infections since 2005, according to two reports published in the March 5 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report
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Few Seniors Receive Regular Brief Cognitive Assessments

WEDNESDAY, March 6, 2019 (Pharmacist's Briefing) -- Only 16 percent of seniors receive regular cognitive assessments, according to the Alzheimer's Disease Facts and Figures report published March 5
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Fluorouracil Cream Best Choice for Tx of Actinic Keratosis Lesions

WEDNESDAY, March 6, 2019 (Pharmacist's Briefing) -- For patients with multiple actinic keratosis lesions on the head, 5 percent fluorouracil cream is the most effective treatment, according to a study published in the March 7 issue of the New England Journal of Medicine
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Program in Peds Rheumatology Clinic Ups Education on Teratogenic Rx

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- A series of interventions introduced through a quality improvement project can increase the frequency of both teratogen education and urine pregnancy screening in patients taking teratogenic medications for rheumatic disease, according to a study published online March 5 in Pediatrics
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Recommendations Developed for Ulcerative Colitis Management

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- Recommendations have been developed for management of adults with ulcerative colitis (UC); the American College of Gastroenterology clinical guideline was published online Feb. 21 in the American Journal of Gastroenterology
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Problems Identified With Gaps in EHR Functionality in Morning Rounds

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- There is a considerable amount of variability in the ways in which electronic health records (EHRs) are used during morning rounds, resulting in extensive use of workarounds and problems with team communication, according to a study published online Feb. 25 in PLOS ONE
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Low-Dose Aspirin Does Not Cut Death From Prostate Cancer

MONDAY, March 4, 2019 (Pharmacist's Briefing) -- Low-dose aspirin use does not appear to reduce the overall risk for prostate cancer death, according to a study published online March 5 in the Annals of Internal Medicine
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