HEALINE

Weekly Summary -- May 17, 2019

Friday, May. 17, 2019 (Pharmacist's Briefing) -- Here are what Pharmacist's Briefing editors consider the most important developments for the week of May 17, 2019

Sugary Drinks and Fruit Juice May Increase Risk of Early Death

FRIDAY, May 17, 2019 (Pharmacist's Briefing) -- Most folks know that sugary drinks aren't healthy, but a new study finds fruit juices are not much better.

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Colon Cancer Increasingly Striking the Young Worldwide

FRIDAY, May 17, 2019 (Pharmacist's Briefing) -- The rise in colon cases among younger adults that's been seen in the United States is also occurring in wealthier nations worldwide, new research shows.

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Suicides Increase Among U.S. Kids, But More in Girls Than Boys

FRIDAY, May 17, 2019 (Pharmacist's Briefing) -- Suicide rates are on the rise among American children, but the increase is greatest among girls, a new study finds.

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Scientists Spot Unexpected Player in Fibromyalgia

THURSDAY, May 16, 2019 (Pharmacist's Briefing) -- Fibromyalgia is a mysterious and misunderstood illness, but researchers may have uncovered at least one key to the disease's origin: insulin resistance.

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Heroin ODs Have Started Declining in Some States

THURSDAY, May 16, 2019 (Pharmacist's Briefing) -- After years of steady increases, the number of Americans showing up in emergency departments with heroin overdoses is on a downswing, at least in some states.

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Weight-Loss Surgery May Work Even Better During Teen Years

THURSDAY, May 16, 2019 (Pharmacist's Briefing) -- The earlier you have weight-loss surgery, the better, a new study suggests.

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Lupus Takes Bigger Toll on Longevity for Blacks

THURSDAY, May 16, 2019 (Pharmacist's Briefing) -- Lupus, a chronic autoimmune disease that attacks the skin, joints and organs, can shorten the lives of its victims, but new research shows it can shorten the lives of black patients the most.

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Less Pain, More Car Crashes: Legalized Marijuana a Mixed Bag

THURSDAY, May 16, 2019 (Pharmacist's Briefing) -- If Colorado is any indication, the legalization of marijuana does not come without health hazards.

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Anxiety Meds Like Valium, Xanax Could Raise Miscarriage Risk

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- Pregnancy is often a time of heightened worry. But researchers warn that taking anti-anxiety drugs like Valium and Xanax may increase the risk of miscarriage.

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Curbing a Skin Oil Might Help Curb Acne, Study Suggests

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- Acne is the bane of many teens, and even some adults. Now, researchers say they might have hit on a new approach to easing the condition.

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Low-Fat Diet Could Be a Weapon Against Breast Cancer

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- Health experts have long touted the benefits of a low-fat diet for preventing heart disease, but now a large study suggests it might do the same against breast cancer.

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Drier Winter Air May Propel Flu's Spread

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- Ever wonder why the flu rarely strikes in the summer?

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Suspect Your Child Has an Ear Infection? There May Soon Be an App for That

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- Can a smartphone app spot an ear infection?

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Brain Bleed Risk Puts Safety of Low-Dose Aspirin in Doubt

TUESDAY, May 14, 2019 (Pharmacist's Briefing) -- Let's say you're one of the millions of older adults who takes a low-dose aspirin religiously, in the belief that it will guard against heart disease and heart attacks.

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Glucosamine Joint Pain Supplement Could Help the Heart

TUESDAY, May 14, 2019 (Pharmacist's Briefing) -- Glucosamine has long been used as a supplement to help ease the joint pain of arthritis, but new research suggests its anti-inflammatory properties might also lower heart disease risk.

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Routine Use of Antibiotics May Help After Complicated Vaginal Birth: Study

TUESDAY, May 14, 2019 (Pharmacist's Briefing) -- Nearly half of infections among women who undergo an assisted vaginal birth could be prevented by giving them a dose of antibiotics soon after delivery, a new study contends.

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Parents, Here's How to Protect Your Child During Measles Outbreaks

TUESDAY, May 14, 2019 (Pharmacist's Briefing) -- As measles outbreaks rage in many parts of the United States, one expert has advice for parents on how to protect their children from the disease.

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Quantity, Not Type of Opioid Matters for Post-Op Dependency

TUESDAY, May 14, 2019 (Pharmacist's Briefing) -- As the United States struggles with a painkiller-abuse epidemic, researchers have found that it's the quantity of opioids prescribed after orthopedic surgery, not the type of opioid, that corresponds with long-term use.

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Young, and Learning Too Late That Sun Safety Matters

TUESDAY, May 14, 2019 (Pharmacist's Briefing) -- The pain Sara Langill felt in her right hip didn't concern her much, until she felt a lump as she massaged tendons near her hip flexors following a soccer game.

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Heart Attack Rehab at Home Could Save Lives

MONDAY, May 13, 2019 (Pharmacist's Briefing) -- If you had a heart attack and could get rehab therapy at home, would you be more likely to get the follow-up care that doctors recommend?

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Body Adapts, Recovers From Occasional 'Pigging Out,' Study Finds

MONDAY, May 13, 2019 (Pharmacist's Briefing) -- It's almost time for long summer weekends and backyard barbecues. And you may be wondering if a day or two of burgers and beers does any long-term damage to your body.

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CBD -- It's Everywhere, But Does It Work?

MONDAY, May 13, 2019 (Pharmacist's Briefing) -- You would have to be living in a cave to have missed the CBD craze that is sweeping across America: New products are cramming store shelves as the market explodes for what many Americans believe to be a miracle cure-all.

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Quitting Smoking Lowers Risk for Bladder Cancer Postmenopause

FRIDAY, May 17, 2019 (Pharmacist's Briefing) -- Among postmenopausal women, former smokers have a reduced risk for bladder cancer within the first 10 years of cessation, which continues to decline over time but remains elevated compared with never smokers, according to a study published in the May issue of Cancer Prevention Research.

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Study Describes TBI Caregiver QOL Measurement System

FRIDAY, May 17, 2019 (Pharmacist's Briefing) -- A new tool, the Traumatic Brain Injury Caregiver Quality of Life (TBI-CareQOL), combines five new measures and 10 existing measures and can identify health-related quality of life (HRQOL) among caregivers of individuals with TBI, according to a study published in the April issue of the Archives of Physical Medicine and Rehabilitation.

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Low-Fat Dietary Pattern Cuts Breast Cancer Deaths

THURSDAY, May 16, 2019 (Pharmacist's Briefing) -- A low-fat dietary intervention is associated with reductions in deaths after breast cancer and deaths from breast cancer among postmenopausal women after long-term follow-up, according to a study scheduled to be presented at the annual meeting of the American Society for Clinical Oncology, held from May 31 to June 4 in Chicago.

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AI Model Uses Serial Imaging to Predict Lung Cancer Tx Response

THURSDAY, May 16, 2019 (Pharmacist's Briefing) -- For patients with locally advanced non-small cell lung cancer (NSCLC), deep-learning networks integrating computed tomography (CT) scans at multiple time points can improve clinical outcome predictions, according to a study published online April 22 in Clinical Cancer Research.

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Poll: Many Adults Worried About Developing Dementia

THURSDAY, May 16, 2019 (Pharmacist's Briefing) -- Many adults are worried about developing dementia and about half report taking steps to maintain or improve memory, according to a report published by the National Poll on Healthy Aging.

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FDA: Tattoo Inks Recalled Due to Bacterial Contamination

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- Six tattoo inks have been recalled because they are contaminated with bacteria and could lead to infection that poses a serious health risk, the U.S. Food and Drug Administration says.

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Worldwide Prevalence of Eating Disorders Increased Since 2000

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- Eating disorders are highly prevalent worldwide, especially among women, according to research published in the May issue of the American Journal of Clinical Nutrition.

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Herpes Zoster Ophthalmicus Cases Increased in 2004 to 2012

TUESDAY, May 14, 2019 (Pharmacist's Briefing) -- From 2004 to 2012, there was a more than threefold increase in the incidence of herpes zoster ophthalmicus (HZO) across the United States, according to a study presented at the annual meeting of the Association for Research in Vision and Ophthalmology, held from April 28 to May 2 in Vancouver, British Columbia, Canada.

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Home-Based Cardiac Rehab May Be Option for Some Heart Patients

TUESDAY, May 14, 2019 (Pharmacist's Briefing) -- For low- to moderate-risk patients, home-based cardiac rehabilitation (HBCR) may be a reasonable alternative to center-based cardiac rehabilitation (CBCR), according to a joint scientific statement issued by the American Association of Cardiovascular and Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology. The statement was published online May 13 in Circulation, the Journal of the American College of Cardiology, and the Journal of Cardiopulmonary Rehabilitation and Prevention.

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Parkinson Disease Risk Up After Appendectomy

MONDAY, May 13, 2019 (Pharmacist's Briefing) -- The risk for Parkinson disease is increased after appendectomy, according to a study presented at the 2019 Digestive Disease Week, held from May 18 to 21 in San Diego.

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Prior Training Increases Internists' Knowledge of PrEP for HIV

MONDAY, May 13, 2019 (Pharmacist's Briefing) -- For internal medicine (IM) residents, prior training is associated with higher levels of knowledge, comfort, and prescribing behaviors for preexposure prophylaxis (PrEP) for HIV, according to a study published online April 24 in the Journal of General Internal Medicine.

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Higher Risk for Cancer, Mortality Seen With Pediatric-Onset IBD

MONDAY, May 13, 2019 (Pharmacist's Briefing) -- Individuals with pediatric-onset inflammatory bowel disease (pIBD) have an increased risk for cancer and mortality, according to a study published online May 9 in Alimentary Pharmacology & Therapeutics.

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Colorectal Cancer Incidence Increasing in Younger Adults

FRIDAY, May 17, 2019 (Pharmacist's Briefing) -- Colorectal cancer incidence is increasing among young adults in certain high-income countries, according to a study published online May 16 in The Lancet Gastroenterology & Hepatology.

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Dabigatran Does Not Beat Aspirin for Preventing Recurrent Stroke

THURSDAY, May 16, 2019 (Pharmacist's Briefing) -- Dabigatran is not superior to aspirin for preventing recurrent stroke in patients with recent history of embolic stroke of undetermined source, according to a study published in the May 16 issue of the New England Journal of Medicine.

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Risk for Miscarriage Up With Benzodiazepine Use in Early Pregnancy

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- The risk for spontaneous abortion (SA) is increased among early pregnancies with incident exposure to benzodiazepines, according to a study published online May 15 in JAMA Psychiatry.

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Habitual Glucosamine Use Linked to Reduced Risk for CVD Events

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- Habitual use of glucosamine supplements is associated with a reduced risk for cardiovascular disease (CVD) events, according to a study published online May 14 in The BMJ.

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Risk for Prolonged Opioid Use Up in Patients Receiving Tramadol

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- Receipt of tramadol alone after surgery is associated with an increased risk for prolonged opioid use, similar to that seen with other short-acting opioids, according to a study published online May 14 in The BMJ.

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Prophylactic Antibiotic Cuts Infection Risk After Operative Vaginal Birth

TUESDAY, May 14, 2019 (Pharmacist's Briefing) -- A single dose of a prophylactic antibiotic is beneficial after operative vaginal birth and reduces the risk for confirmed or suspected maternal infection, according to a study published online May 13 in The Lancet.

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Oral BTK Inhibitor Superior to Placebo in Multiple Sclerosis

TUESDAY, May 14, 2019 (Pharmacist's Briefing) -- The selective Bruton's tyrosine kinase (BTK) inhibitor evobrutinib at a dose of 75 mg once daily is associated with fewer enhancing lesions during weeks 12 through 24 among patients with relapsing multiple sclerosis, according to a study published May 10 in the New England Journal of Medicine to coincide with the annual meeting of the American Academy of Neurology, held from May 4 to 10 in Philadelphia.

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Infection Risk Lower With Certain Psoriasis Treatments

MONDAY, May 13, 2019 (Pharmacist's Briefing) -- For patients with psoriasis treated with systemic medications, the risk for serious infection is reduced for new users of apremilast, etanercept, and ustekinumab versus methotrexate, according to a study published online May 10 in JAMA Dermatology.

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Fournier Gangrene Is Safety Concern With SGLT2 Inhibitors

MONDAY, May 13, 2019 (Pharmacist's Briefing) -- Fournier gangrene (FG) is a safety concern for adults with diabetes receiving treatment with sodium-glucose cotransporter-2 (SGLT2) inhibitors, according to a study published online May 7 in the Annals of Internal Medicine.

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First Anticoagulant Approved for Preventing VTE Recurrence in Children

FRIDAY, May 17, 2019 (Pharmacist's Briefing) -- Fragmin (dalteparin sodium) injection has been granted the first approval for subcutaneous use in preventing recurrence of symptomatic venous thromboembolism (VTE) in children aged 1 month or older, the U.S. Food and Drug Administration announced.

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FDA Approves Venetoclax for Chronic Lymphocytic Leukemia

FRIDAY, May 17, 2019 (Pharmacist's Briefing) -- Venetoclax (VENCLEXTA) has been approved to treat adult patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma, the U.S. Food and Drug Administration announced yesterday.

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Avelumab + Axitinib Approved for Treatment of Renal Cell Carcinoma

FRIDAY, May 17, 2019 (Pharmacist's Briefing) -- Avelumab (BAVENCIO) was approved this week for first-line treatment of advanced renal cell carcinoma (RCC) in combination with axitinib, the U.S. Food and Drug Administration announced.

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Drug Recalls

Updated: May 17, 2019

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Drug Shortages

Updated: May 17, 2019

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Drug Approvals

Updated: May 17, 2019

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Sleep Duration Tied to Adverse Measures of Glycemia

FRIDAY, May 17, 2019 (Pharmacist's Briefing) -- Self-reported short and long sleep are both associated with adverse measures of glycemia among adults with prediabetes, according to a study published online May 10 in Diabetes Care.

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Heroin Overdose ED Visits Decreased From 2017 to 2018

FRIDAY, May 17, 2019 (Pharmacist's Briefing) -- From 2017 to 2018, there was a decrease in heroin overdose emergency department visits, although the declines were not consistent among states, according to a study published online May 16 in the American Journal of Public Health.

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Cannabis Legalization Not Tied to Higher Health Care Utilization

THURSDAY, May 16, 2019 (Pharmacist's Briefing) -- Legalization of recreational cannabis is not associated with changes in health care utilization, as measured by length of stay or health care costs, according to a study published in the May issue of BMJ Open.

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Smartphone App Could Help Diagnose Ear Infections

THURSDAY, May 16, 2019 (Pharmacist's Briefing) -- A smartphone could be used as a screening tool for detecting the presence of middle ear fluid, according to a proof-of-concept study published in the May 15 issue of Science Translational Medicine.

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Opioid Quantity Prescribed After Musculoskeletal Injury Tied to Prolonged Use

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- Opioid- naive patients treated for a surgical musculoskeletal injury, the quantity of opioid prescribed, but not opioid type, is associated with prolonged opioid use, according to a study published in the May 1 issue of the Journal of the American Academy of Orthopaedic Surgeons.

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Thyroid Hormones Not Endorsed for Subclinical Hypothyroidism

WEDNESDAY, May 15, 2019 (Pharmacist's Briefing) -- Thyroid hormones are not recommended for adults with subclinical hypothyroidism (SCH), according to an article published online May 14 in The BMJ.

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Patients Find Note Reading Important for Health Management

TUESDAY, May 14, 2019 (Pharmacist's Briefing) -- Patients find note reading important for their health management and are rarely troubled by what they read, according to a study published in the May issue of the Journal of Medical Internet Research.

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Late-Onset Type 1 Diabetes Often Misdiagnosed as Type 2

TUESDAY, May 14, 2019 (Pharmacist's Briefing) -- Type 1 diabetes diagnosed in those older than age 30 years is clinically and biologically similar to disease occurring at younger ages but is often misidentified, according to a study recently published in Diabetologia.

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Heart Patients at Risk When Pharmacies Close

MONDAY, May 13, 2019 (Pharmacist's Briefing) -- When pharmacies close, people with heart disease stop taking widely used heart medications, such as statins, beta-blockers, and oral anticoagulants, according to a study published online April 19 in JAMA Network Open.

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Health Professionals Supportive of Medicinal Cannabis

MONDAY, May 13, 2019 (Pharmacist's Briefing) -- Health professionals are generally supportive of medicinal cannabis use but report a lack of knowledge about its use, according to a review published online May 6 in PLOS ONE.

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