HEALINE

Test Predicts Benefit of Chemo in ER+, HER2− Breast Cancer

EndoPredict, a multigene test, helps predict whether adjuvant chemotherapy would be beneficial

THURSDAY, May 9, 2019 (Pharmacist's Briefing) -- EndoPredict (EPclin) is prognostic for distant recurrence (DR) in women with estrogen receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer, according to a study published online April 30 in Breast Cancer Research and Treatment.

Ivana Sestak, Ph.D., from Queen Mary University of London, and colleagues examined the performance of EPclin for estimating 10-year DR-free interval rates for 2,630 women receiving five years of endocrine therapy (ET) alone and 1,116 patients receiving ET + chemotherapy (C).

The researchers found that in women who received ET alone and in those who received ET + C, EPclin was highly prognostic for DR (hazard ratios, 2.79 and 2.27, respectively). Significantly smaller increases in 10-year DR rates with the increasing EPclin score were seen for women who received ET + C compared with those receiving ET alone (EPClin = 5; 12 percent for ET + C versus 20 percent for ET alone). A significant positive interaction was seen between EPclin and treatment groups.

"It is clinically important to determine which women with hormone receptor-positive, HER2-negative breast cancer need chemotherapy in addition to standard five-years of hormonal treatment," Sestak said in a statement. "We have shown that EndoPredict has the ability to predict chemotherapy benefit, which will ultimately help clinicians in their decision-making process about adjuvant treatment."

Several authors disclosed financial ties to the biopharmaceutical industry.

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