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Weekly Summary -- May 3, 2019

Friday, May. 3, 2019 (Pharmacist's Briefing) -- Here are what Pharmacist's Briefing editors consider the most important developments for the week of May 3, 2019

Could Common Heart Meds Lower Prostate Cancer Risk?

FRIDAY, May 3, 2019 (Pharmacist's Briefing) -- Good news for men: That blood pressure medication you're taking might be doing double duty, helping reduce your risk of developing prostate cancer, a new study shows.

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How to Know If Your PMS Is Something More Serious

FRIDAY, May 3, 2019 (Pharmacist's Briefing) -- A severe and potentially disabling form of premenstrual syndrome (PMS) affects up to 5% of women of childbearing age, an expert says.

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Breast Surgeons' Group Issues New Mammogram Guidelines

FRIDAY, May 3, 2019 (Pharmacist's Briefing) -- The largest organization representing U.S. breast surgeons is issuing new screening guidelines, advising women at average risk to begin annual mammograms at age 40.

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Not Just Opioids: Deaths Tied to Cocaine, Meth Are Soaring, Too

THURSDAY, May 2, 2019 (Pharmacist's Briefing) -- As the United States battles an ongoing epidemic of opioid abuse and deaths, new data shows that fatalities tied to cocaine and methamphetamines are also surging.

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'Ringing in the Ears' May Drive Some to the Brink of Suicide

THURSDAY, May 2, 2019 (Pharmacist's Briefing) -- Imagine a ringing in your ears so intense and unrelenting that you become desperate enough to try to kill yourself.

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HIV Meds Cut Transmission Risk to Zero, Even Without Condoms: Study

THURSDAY, May 2, 2019 (Pharmacist's Briefing) -- Even if they never use a condom during sex, gay men whose HIV is undetectable due to ongoing antiretroviral treatment cannot infect their male partner, new research reveals.

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Device Spots Lymphedema Early in Breast Cancer Patients, to Help Stop It

THURSDAY, May 2, 2019 (Pharmacist's Briefing) -- An easy-to-use, noninvasive device can detect early signs of the cancer complication known as lymphedema, a new study reports.

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Overdose Attempts Skyrocket Among Teens, Young Adults: Study

WEDNESDAY, May 1, 2019 (Pharmacist's Briefing) -- Suicide attempts by drug overdoses and other "self-poisonings" more than doubled among U.S. youth in the last decade, a new study reveals.

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Treatments Targeting Social Behavior Hormone Show Promise With Autism

WEDNESDAY, May 1, 2019 (Pharmacist's Briefing) -- Hormone-based treatment might improve social function in people with autism, a pair of new clinical trials suggests.

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Male-Hormone Gene May Help Cause Polycystic Ovary Syndrome

WEDNESDAY, May 1, 2019 (Pharmacist's Briefing) -- Polycystic ovary syndrome is a common cause of infertility and type 2 diabetes, but little is known about its origins. Now, new research suggests a gene involved in male hormone production plays a big role in the disorder's development.

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U.S. Teen Opioid Deaths Soaring

TUESDAY, April 30, 2019 (Pharmacist's Briefing) -- The number of American children and teens who have lost their lives to opioids has nearly tripled since 1999, a new report shows.

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More Evidence CBD Can Help Ease a Form of Epilepsy in Kids

TUESDAY, April 30, 2019 (Pharmacist's Briefing) -- There's new data supporting the use of Epidiolex -- the first cannabidiol (CBD) medicine approved by the U.S. Food and Drug Administration -- to help curb a form of epilepsy.

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Asthma Inhalers Incorrectly Used by Most Kids in Study

TUESDAY, April 30, 2019 (Pharmacist's Briefing) -- Asthma inhalers can't do the job if they're not used correctly. And that's an issue for many children, U.S. researchers say.

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Newer Diabetes Drug Shows Promise in Kids, Teens

TUESDAY, April 30, 2019 (Pharmacist's Briefing) -- A type 2 diabetes drug for adults also controls blood sugar levels in children and teens with the disease, researchers report.

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Your Virtual Doctor Will 'See' You Now

TUESDAY, April 30, 2019 (Pharmacist's Briefing) -- Need to see your doctor, but can't take time off from work? There's an app for that. And new research shows patients find the ability to see a doctor "virtually" convenient and satisfying.

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High Measles Rates Mean Kids, Adults Need Proper Vaccination: CDC

MONDAY, April 29, 2019 (Pharmacist's Briefing) -- As the once-vanquished measles virus continues to spread through U.S. communities, federal health officials on Monday urged up-to-date vaccination for children and some adults.

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Does Diet Affect a Child's ADHD?

MONDAY, April 29, 2019 (Pharmacist's Briefing) -- Parents of kids with attention-deficit hyperactivity disorder (ADHD) may change their child's diet in the hope it might ease the disorder's symptoms.

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Parents, Protect Your Kids as Measles Outbreaks Spread

MONDAY, April 29, 2019 (Pharmacist's Briefing) -- As measles outbreaks spread across the United States, there are a number of things parents need to know, a leading pediatricians' group says.

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CDC: Foodborne Infections Increased From 2015 to 2018

FRIDAY, May 3, 2019 (Pharmacist's Briefing) -- From 2015 to 2018, the incidence of most foodborne infections increased, according to research published in the April 26 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Cocaine-, Psychostimulant-Involved Death Rates Increasing

THURSDAY, May 2, 2019 (Pharmacist's Briefing) -- Drug overdose deaths involving cocaine and psychostimulants accounted for 19.8 and 14.7 percent, respectively, of all 2017 drug overdose deaths, and the death rates are continuing to increase, according to research published in the May 3 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Model Predicts Progression Risk for Rare Type of Lymphoma

FRIDAY, May 3, 2019 (Pharmacist's Briefing) -- A publicly available model can identify patients with asymptomatic Waldenström macroglobulinemia (AWM) at high risk for progression, according to a study published online April 16 in the Journal of Clinical Oncology.

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Prior Authorization Obstacles Delaying Treatment

THURSDAY, May 2, 2019 (Pharmacist's Briefing) -- Prior authorization obstacles are delaying patient access to radiation oncology treatments, according to a survey released by the American Society for Radiation Oncology.

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Childhood Oral Infection Linked to Atherosclerosis in Adulthood

THURSDAY, May 2, 2019 (Pharmacist's Briefing) -- Oral infections in childhood are associated with subclinical carotid atherosclerosis in adulthood, according to a study published online April 26 in JAMA Network Open.

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Cognitive Function Does Not Predict Pediatric Bariatric Surgery Outcome

WEDNESDAY, May 1, 2019 (Pharmacist's Briefing) -- Youth with cognitive impairment or developmental disability (CI/DD) have weight-loss trajectories after bariatric surgery similar to those of their peers with typical cognitive function, according to a study published online in the May issue of Pediatrics.

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'Vampire Facials' at New Mexico Spa Linked to HIV Infections

WEDNESDAY, May 1, 2019 (Pharmacist's Briefing) -- Two people may have contracted HIV after undergoing so-called "vampire facials" at a New Mexico spa, state health officials say.

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Living Alone Tied to Increased Risk for Mental Disorders

WEDNESDAY, May 1, 2019 (Pharmacist's Briefing) -- Living alone is positively associated with common mental disorders (CMDs) in the general population in England, according to a study published online May 1 in PLOS ONE.

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Diagnostic Criteria Proposed for Advanced-Age Proteinopathy

WEDNESDAY, May 1, 2019 (Pharmacist's Briefing) -- Progress has been made toward developing diagnostic criteria for limbic-predominant age-related TDP-43 encephalopathy (LATE), although gaps remain in understanding, according to a report published online April 30 in Brain.

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Radical Hemithoracic Radiation Tx Ups Survival in Mesothelioma

WEDNESDAY, May 1, 2019 (Pharmacist's Briefing) -- For patients with malignant pleural mesothelioma (MPM), overall survival (OS) is significantly improved with radical hemithoracic radiotherapy (RHR) versus palliative radiotherapy (PR), according to a study presented at ESTRO 38, the annual meeting of the European Society for Radiotherapy and Oncology, held from April 26 to 30 in Milan.

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Adopted Children Should Undergo Comprehensive Health Evaluation

TUESDAY, April 30, 2019 (Pharmacist's Briefing) -- Children who join families through the process of adoption should undergo a comprehensive health evaluation shortly after placement in an adoptive home, according to a clinical report published online April 29 in Pediatrics.

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Targeted Therapy Promising for Rare Hematologic Cancer

TUESDAY, April 30, 2019 (Pharmacist's Briefing) -- Tagraxofusp appears effective for treating the rare aggressive hematologic cancer blastic plasmacytoid dendritic-cell neoplasm (BPDCN), according to a study published in the April 25 issue of the New England Journal of Medicine.

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Work Stress, Impaired Sleep Tied to CVD Risk in Workers With HTN

TUESDAY, April 30, 2019 (Pharmacist's Briefing) -- Work stress and impaired sleep are associated with an increased risk for cardiovascular disease (CVD) mortality among workers with hypertension, according to a study published online April 27 in the European Journal of Preventive Cardiology.

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EHR Decision Support Can Reduce Inappropriate GI Testing

MONDAY, April 29, 2019 (Pharmacist's Briefing) -- Electronic health record (EHR) decision support reduces inappropriate use of an expensive gastrointestinal test for patients hospitalized with diarrhea, according to a study published online April 23 in Infection Control & Hospital Epidemiology.

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EHR Decision Support Can Reduce Inappropriate GI Testing

MONDAY, April 29, 2019 (Pharmacist's Briefing) -- Electronic health record (EHR) decision support reduces inappropriate use of an expensive gastrointestinal test for patients hospitalized with diarrhea, according to a study published online April 23 in Infection Control & Hospital Epidemiology.

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ART Stops HIV Transmission in Serodifferent Gay Couples

FRIDAY, May 3, 2019 (Pharmacist's Briefing) -- In HIV serodifferent gay couples, the within-couple rate of HIV transmission through condomless anal sex is zero when the HIV-positive partner is taking suppressive antiretroviral therapy (ART), according to a study published online May 2 in The Lancet.

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Impact of Azithromycin Studied in Acute Exacerbation of COPD

FRIDAY, May 3, 2019 (Pharmacist's Briefing) -- Three months of azithromycin did not significantly reduce treatment failure (TF) among patients hospitalized for an acute exacerbation of chronic obstructive pulmonary disease (AECOPD), according to a study published online May 3 in the American Journal of Respiratory and Critical Care Medicine.

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Prolonged Exposure to Low-Dose Radiation May Increase HTN Risk

FRIDAY, May 3, 2019 (Pharmacist's Briefing) -- For Russian Mayak nuclear enterprise workers occupationally exposed to ionizing radiation, hypertension incidence is associated with cumulative liver-absorbed dose from external γ-rays, according to a study published online May 3 in Hypertension.

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Prepregnancy Folate Intake Linked to Reduced Risk for GDM

THURSDAY, May 2, 2019 (Pharmacist's Briefing) -- Higher prepregnancy habitual folate intake from supplements is associated with a lower risk for gestational diabetes mellitus (GDM), according to a study published online April 22 in Diabetes Care.

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Psoriasis Symptoms, Quality of Life Tied to Disease Severity

THURSDAY, May 2, 2019 (Pharmacist's Briefing) -- Patient-reported symptoms of psoriasis, quality of life, and work productivity worsen with increasing disease severity, as measured by two established clinician assessment tools, according to a study published online April 20 in BMJ Open.

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Patients Satisfied With Oral Sedation for Cataract Surgery

THURSDAY, May 2, 2019 (Pharmacist's Briefing) -- Using oral sedation during cataract surgery does not negatively impact patient satisfaction compared with using an intravenous (IV) sedative, according to a study published online April 16 in Ophthalmology.

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Patient Hand Contamination With Drug-Resistant Organisms Common

WEDNESDAY, May 1, 2019 (Pharmacist's Briefing) -- Patient hand contamination with multidrug-resistant organisms (MDROs) is common and correlates with contamination on high-touch hospital room surfaces, according to a study published online April 13 in Clinical Infectious Diseases.

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Thiazide Use May Lower Fracture Risk in Patients With Alzheimer Disease

WEDNESDAY, May 1, 2019 (Pharmacist's Briefing) -- Community-dwelling patients with Alzheimer disease (AD) experience a lower risk for fractures, including hip fractures, with thiazide use, according to a study published online April 16 in Osteoporosis International.

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Combo Nicotine Replacement Tx Ups Success in Quitting Smoking

TUESDAY, April 30, 2019 (Pharmacist's Briefing) -- People who use combination nicotine replacement therapy (NRT) are more likely to successfully quit smoking than people who use a single form of NRT, according to a review published online April 18 in the Cochrane Database of Systematic Reviews.

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Postchemo Radiation Tx May Benefit Some With Hodgkin Lymphoma

TUESDAY, April 30, 2019 (Pharmacist's Briefing) -- For patients with advanced-stage Hodgkin lymphoma (HL) with large tumors, limited evidence suggests that consolidation radiotherapy (RT) after chemotherapy may prolong progression-free survival, according to a study presented at ESTRO 38, the annual meeting of the European Society for Radiotherapy and Oncology, held from April 26 to 30 in Milan.

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Liraglutide Added to Metformin Effective for Type 2 Diabetes

MONDAY, April 29, 2019 (Pharmacist's Briefing) -- The addition of liraglutide to metformin is effective and safe for children and adolescents with type 2 diabetes, according to a study published online April 28 in the New England Journal of Medicine to coincide with the annual meeting of the Pediatric Academic Societies, held from April 24 to May 1 in Baltimore.

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Intensive Blood Pressure Therapy Aids Patients With T2DM

MONDAY, April 29, 2019 (Pharmacist's Briefing) -- Patients with type 2 diabetes who receive intensive treatment to keep their blood pressure levels at 130/80 mm Hg or below experience fewer heart attacks, strokes, and other diabetes complications, according to a study published online April 29 in Hypertension.

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Longer Duration of Antibiotic Use Tied to Risk for CVD in Women

FRIDAY, April 26, 2019 (Pharmacist's Briefing) -- For women in middle and late adulthood, longer duration of antibiotic use is associated with an increased risk for cardiovascular disease (CVD) events, according to a study published online April 24 in the European Heart Journal.

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FDA Approves Dengue Vaccine for Endemic Regions

FRIDAY, May 3, 2019 (Pharmacist's Briefing) -- The dengue vaccine Dengvaxia has been approved by the U.S. Food and Drug Administration for use in the U.S. territories of American Samoa, Guam, Puerto Rico, and the U.S. Virgin Islands, but its use is limited to people aged 9 to 16 years. The vaccine has already been approved in 19 countries and the European Union.

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More Than Half of U.S. Adults Have Medical Financial Hardship

FRIDAY, May 3, 2019 (Pharmacist's Briefing) -- Medical financial hardship affects more than half of adults in the United States, according to a study published online May 1 in the Journal of General Internal Medicine.

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Out-of-Pocket Costs for Neurologic Meds Have Increased

THURSDAY, May 2, 2019 (Pharmacist's Briefing) -- From 2004 to 2016, there was a considerable increase in out-of-pocket costs for neurologic medications, especially for those in high-deductible health plans, according to a study published online May 1 in Neurology.

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New Drugs May Influence Social Behaviors in Those With Autism

THURSDAY, May 2, 2019 (Pharmacist's Briefing) -- Balovaptan, an orally administered selective vasopressin V1a receptor antagonist, is associated with improved adaptive behaviors for men with autism spectrum disorder (ASD), while arginine vasopressin (AVP), a neuropeptide involved in promoting mammalian social behaviors, may improve social impairments in children with ASD, according to two phase 2 studies published online May 1 in Science Translational Medicine.

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FDA Approves Mavyret for Children, Adolescents With Hep C

WEDNESDAY, May 1, 2019 (Pharmacist's Briefing) -- Mavyret (glecaprevir and pibrentasvir) tablets are now approved to treat all six genotypes of hepatitis C virus (HCV) in children ages 12 to 17 years, the U.S. Food and Drug Administration announced yesterday.

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AAN: Cannabidiol Tied to Drop in Seizures in Dravet Syndrome

WEDNESDAY, May 1, 2019 (Pharmacist's Briefing) -- For patients with Dravet syndrome (DS) and drug-resistant seizures, cannabidiol (CBD) is associated with a reduction in seizures, according to a study scheduled to be presented at the annual meeting of the American Academy of Neurology, held from May 4 to 10 in Philadelphia.

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Prevalence of Workplace Health Promotion Programs Low

TUESDAY, April 30, 2019 (Pharmacist's Briefing) -- Across U.S. worksites, the prevalence of workplace health promotion (WHP) programs has increased but still remains low, according to a study published online April 22 in the American Journal of Health Promotion.

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Confidence in Inhaler Technique Poor Proxy for Correct Use

TUESDAY, April 30, 2019 (Pharmacist's Briefing) -- Child and parent confidence are poor proxies for proper inhaler use among African-American children with asthma, according to a study published online April 30 in the Annals of Allergy, Asthma & Immunology.

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FDA Approves First Treatment for Pediatric Lupus

MONDAY, April 29, 2019 (Pharmacist's Briefing) -- The first treatment has been approved for children with systemic lupus erythematosus (SLE), the U.S. Food and Drug Administration announced Friday.

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12 Percent of Caregivers Have Pediatric Flu Vaccine Hesitancy

MONDAY, April 29, 2019 (Pharmacist's Briefing) -- Some caregivers of children have influenza vaccine hesitancy and hold inaccurate beliefs about influenza vaccination and disease, according to a study presented at the annual meeting of the Pediatric Academic Societies, held from April 24 to May 1 in Baltimore.

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