HEALINE

Weekly Summary -- April 26, 2019

Friday, Apr. 26, 2019 (Pharmacist's Briefing) -- Here are what Pharmacist's Briefing editors consider the most important developments for the week of April 26, 2019

VA Doctors Prescribing Unnecessary Antibiotics, Study Says

FRIDAY, April 26, 2019 (Pharmacist's Briefing) -- Antibiotic overuse is a major problem throughout the world. Now a new study finds four in 10 outpatients were inappropriately prescribed antibiotics at a major U.S. Veterans Affairs health system.

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Study Supports Radiation for Early, Hormone-Driven Breast Cancer

FRIDAY, April 26, 2019 (Pharmacist's Briefing) -- For women with hormone-driven breast cancer, adding radiation to hormone therapy might keep their cancer from coming back for up to a decade, a new study finds.

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Fatal Drug ODs Surging Among Young Americans

THURSDAY, April 25, 2019 (Pharmacist's Briefing) -- The cost of America's opioid epidemic just keeps rising, with new research showing that overdose deaths among teens and young adults are soaring.

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As U.S. Measles Cases Hit New High, Experts Warn the Disease Can Be Deadly

THURSDAY, April 25, 2019 (Pharmacist's Briefing) -- Measles cases in the United States have now reached 695 -- the highest since the disease was declared eliminated in 2000, the U.S. Centers for Disease Control and Prevention announced late Wednesday.

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After a Stroke, Your Bones Need Care

THURSDAY, April 25, 2019 (Pharmacist's Briefing) -- Stroke survivors often face limited mobility, which quadruples their odds of osteoporosis, broken bones and falls. But most are never screened for these problems, new research reveals.

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Is Peanut Allergy 'Immunotherapy' Causing More Harm Than Good?

THURSDAY, April 25, 2019 (Pharmacist's Briefing) -- The idea behind immunotherapy for peanut allergy is appealing in its simplicity: Ask a patient to eat tiny amounts of peanut every day, and over time their immune system will become desensitized to it.

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Long-Term Antibiotic Use May Up Women's Odds for Heart Trouble

THURSDAY, April 25, 2019 (Pharmacist's Briefing) -- Antibiotics can be lifesaving, but using them over a long period might raise the odds of heart disease and stroke in older women, a new study suggests.

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Many E-Cigs Loaded With Germs, Study Finds

WEDNESDAY, April 24, 2019 (Pharmacist's Briefing) -- You might need to worry about inhaling more than just nicotine when you vape: New research warns that many electronic cigarettes appear to be contaminated with fungi and bacteria.

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Pregnant? The Earlier You Quit Smoking, the Better

WEDNESDAY, April 24, 2019 (Pharmacist's Briefing) -- Quitting smoking during pregnancy reduces the risk of delivering preterm. And the earlier you stop, the better, a new study finds.

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Fatal Medical Emergencies on the Rise Worldwide: Study

WEDNESDAY, April 24, 2019 (Pharmacist's Briefing) -- Injuries, heart attacks, lung infections, strokes and other medical emergencies caused about half of the world's 28 million deaths in 2015, a new study reports.

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Don't Assume Pot Will Make You Fat

WEDNESDAY, April 24, 2019 (Pharmacist's Briefing) -- Even though marijuana triggers the "munchies" in many people, adults who use the drug tend to weigh less than nonusers, a new study finds.

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'Two Wave' Flu Season Unusually Long: CDC

TUESDAY, April 23, 2019 (Pharmacist's Briefing) -- What looked like a mild flu season in December has turned into the longest flu season in five years, U.S. health officials report.

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Skipping Breakfast Could Be a Bad Move for Your Heart

TUESDAY, April 23, 2019 (Pharmacist's Briefing) -- Think breakfast isn't the most important meal of the day?

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Americans Sitting More Than Ever, and Tech Is to Blame

TUESDAY, April 23, 2019 (Pharmacist's Briefing) -- America's couch potatoes are becoming ever more deeply rooted, and computers are the reason why.

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Veggies, Fruits and Grains Keep Your Heart Pumping

TUESDAY, April 23, 2019 (Pharmacist's Briefing) -- As if you needed any more proof that fruits, vegetables and whole grains are good for you, a new study finds they may cut your chances of heart failure by 41%.

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Quick Test Helps Predict Hospital Readmission Risk After Heart Attack

TUESDAY, April 23, 2019 (Pharmacist's Briefing) -- For elderly heart attack survivors, how well they perform on a simple mobility test could help predict whether they will be back in the hospital within a month, researchers say.

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Can Obesity Shrink Your Brain?

TUESDAY, April 23, 2019 (Pharmacist's Briefing) -- Obese people may show some shrinkage in their brain tissue as early as middle age, a large new study confirms.

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Video Games Don't Hamper Boys' Social Skills, Study Finds

TUESDAY, April 23, 2019 (Pharmacist's Briefing) -- Does playing a lot of video games really jeopardize a boy's ability to make and keep friends?

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Can Pregnancy Put a Damper on Your Career?

TUESDAY, April 23, 2019 (Pharmacist's Briefing) -- Many American women feel less welcome at work once they become pregnant, a new study finds.

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Many Teens Don't Know They Are Vaping Nicotine

MONDAY, April 22, 2019 (Pharmacist's Briefing) -- As e-cigarette use soars in high schools across America, new research shows many people don't understand the amount of addictive nicotine they're inhaling with every puff.

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Strict Blood Pressure Limits for Kids Tied to Heart Health Later

MONDAY, April 22, 2019 (Pharmacist's Briefing) -- Tighter high blood pressure guidelines for children might better spot those at risk for heart disease in adulthood, a new study suggests.

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Medical Marijuana Use Rising Among Cancer Patients

MONDAY, April 22, 2019 (Pharmacist's Briefing) -- Americans with cancer are more likely to use marijuana and prescription opioids than those without cancer, and the use of medical marijuana by this group is on the rise, new research shows.

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Improvement Needed in Doctor-Patient Lung Cancer Screening Discussions

FRIDAY, April 26, 2019 (Pharmacist's Briefing) -- Among individuals across the spectrum of lung cancer risk, efforts are needed to improve physician-patient discussion about lung cancer screening, according to a study published online April 25 in Cancer Epidemiology, Biomarkers & Prevention.

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Children With ADHD May Have Higher Risk for Poor Diet

FRIDAY, April 26, 2019 (Pharmacist's Briefing) -- Children with more attention-deficit/hyperactivity disorder (ADHD) symptoms may be at higher risk for an unhealthy diet, but diet quality does not appear to affect ADHD risk, according to a study published in the April issue of The Journal of Nutrition.

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Swapping Red Meat for Plant-Based Proteins May Cut CVD Risk

FRIDAY, April 26, 2019 (Pharmacist's Briefing) -- Substituting red meat with high-quality plant protein sources, but not with fish or low-quality carbohydrates, leads to greater improvements in blood lipids and lipoproteins, according to a review published online April 9 in Circulation.

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Telerehabilitation Aids Function, Pain With Advanced Cancer

FRIDAY, April 26, 2019 (Pharmacist's Briefing) -- Collaborative telerehabilitation modestly improves function and pain while decreasing hospital length of stay and the need for postacute care in advanced cancer patients, according to a study published online April 4 in JAMA Oncology.

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Eating Breakfast Tied to Lower Risk for Death From CVD

THURSDAY, April 25, 2019 (Pharmacist's Briefing) -- Skipping breakfast is significantly associated with an increased risk for death from heart disease, according to a study published in the April 30 issue of the Journal of the American College of Cardiology.

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Stroke Patients Infrequently Screened, Treated for Bone Loss

THURSDAY, April 25, 2019 (Pharmacist's Briefing) -- Patients with recent stroke are rarely screened and treated for osteoporosis, according to a study published online April 25 in Stroke.

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Interdisciplinary Care Pathway Helps Manage Frail, Elderly Trauma Patients

THURSDAY, April 25, 2019 (Pharmacist's Briefing) -- An interdisciplinary care protocol for frail geriatric trauma patients significantly reduces the risk for delirium and 30-day readmission, according to a study published online April 5 in the Journal of the American College of Surgeons.

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Emergency Medical Diseases Account for About Half of Mortality

THURSDAY, April 25, 2019 (Pharmacist's Briefing) -- Emergency medical diseases (EMDs) contribute to about half of mortality and two-fifths of the burden of diseases globally, according to a study recently published in BMJ Global Health.

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Risk Factors ID'd for Rheumatoid Arthritis Complications

WEDNESDAY, April 24, 2019 (Pharmacist's Briefing) -- A new study published online April 11 in the International Journal of Rheumatic Diseases identifies factors tied to hospitalization and infections among patients with rheumatoid arthritis (RA).

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Over Half of Seniors Initiating Dialysis Die Within One Year

WEDNESDAY, April 24, 2019 (Pharmacist's Briefing) -- More than half of Medicare beneficiaries initiating dialysis die within one year, according to a research letter published online April 22 in JAMA Internal Medicine.

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Low Socioeconomic Position Linked to Poor End-of-Life Care

WEDNESDAY, April 24, 2019 (Pharmacist's Briefing) -- Low socioeconomic position (SEP) is a risk factor for potentially poor-quality end-of-life care, including hospital death, according to research published online April 23 in PLOS Medicine.

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Outcomes Worse for Cancer Patients Seen at Noncancer EDs

TUESDAY, April 23, 2019 (Pharmacist's Briefing) -- Patients with cancer who are seeking cancer-related emergency medical care have worse outcomes when they are seen at alternative hospitals or those not associated with a cancer center, according to a study published in the April 23 issue of CMAJ, the journal of the Canadian Medical Association.

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Cognitive Behavioral Therapy Aids Irritable Bowel Symptoms

TUESDAY, April 23, 2019 (Pharmacist's Briefing) -- Both telephone-delivered and web-delivered cognitive behavioral therapy (CBT) can significantly improve irritable bowel syndrome (IBS) symptoms, according to a study published online April 10 in Gut.

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High Resting Heart Rate Linked to Increased Cardiac Risk in Men

MONDAY, April 22, 2019 (Pharmacist's Briefing) -- High resting heart rate (RHR) is associated with an increased risk for death and cardiovascular events in men, according to a study published online April 15 in Open Heart.

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Cardiometabolic Risk Better ID'd in Children Reclassified to Higher BP

MONDAY, April 22, 2019 (Pharmacist's Briefing) -- Children reclassified to higher blood pressure categories based on 2017 pediatric hypertension definitions are at increased risk for developing adverse cardiometabolic outcomes, according to a study published online April 22 in Hypertension.

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Many With Chronic Pain Achieve Remission From Suicidality

FRIDAY, April 26, 2019 (Pharmacist's Briefing) -- Almost two-thirds of formerly suicidal Canadians with chronic pain were free from suicidal thoughts in the previous year, according to a study published online April 9 in The Journal of Pain.

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Dapagliflozin Improves Glucose Outcomes in Type 1 Diabetes

FRIDAY, April 26, 2019 (Pharmacist's Briefing) -- In patients with type 1 diabetes, treatment with dapagliflozin for 24 weeks improves time in range, mean glucose, and glycemic variability, according to a study published online April 9 in Diabetes Care.

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Peanut Oral Immunotherapy Appears Safe for Preschool-Age Children

THURSDAY, April 25, 2019 (Pharmacist's Briefing) -- Preschool peanut oral immunotherapy (P-OIT) is safe in a real-world setting, although life-threatening reactions can occur in a minority of patients, according to a study published online April 17 in the Journal of Allergy and Clinical Immunology: In Practice.

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Naproxen Sodium Does Not Slow Presymptomatic Alzheimer Disease

THURSDAY, April 25, 2019 (Pharmacist's Briefing) -- Naproxen sodium twice daily is not associated with reduced progression of presymptomatic Alzheimer disease (AD) among cognitively intact people at risk for the condition, according to a study published online April 5 in Neurology.

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Sucking Ice Chips Cuts Oral Side Effects of Oxaliplatin Chemo

WEDNESDAY, April 24, 2019 (Pharmacist's Briefing) -- Chemotherapy patients who suck on ice chips during treatment with oxaliplatin infusion have less trouble with eating and drinking cold things, fewer negative effects on quality of life due to oral symptoms, and a shorter duration of oral symptoms, according to a study published in the April issue of the Journal of the National Comprehensive Cancer Network.

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Personalizing Breast Cancer Tx Could Cut Initial Costs of Care

WEDNESDAY, April 24, 2019 (Pharmacist's Briefing) -- Personalizing breast cancer treatment based on Oncotype DX recurrence scores could result in small decreases in costs in the initial 12 months of care, according to a study published online April 24 in the Journal of the National Cancer Institute.

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Risk-Based Screening Improves Cardiovascular Disease Prevention

WEDNESDAY, April 24, 2019 (Pharmacist's Briefing) -- Cardiovascular risk screening intervals based on risk category-specific progression rates would perform better and improve cost-effectiveness compared with established five-year screening intervals, according to a study published in the April issue of The Lancet Public Health.

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Individualized Medical-Nutrition Therapy Important in Diabetes

TUESDAY, April 23, 2019 (Pharmacist's Briefing) -- Diabetes-focused medical nutrition therapy (MNT) is fundamental to overall diabetes management and should be adapted as needed throughout life, according to a consensus report published in the May issue of Diabetes Care.

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Rates of Marijuana Use in Cancer Patients on the Rise in U.S.

MONDAY, April 22, 2019 (Pharmacist's Briefing) -- Many people with cancer use marijuana, and the rates of use in the United States have increased over time, according to a study published online April 22 in Cancer.

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Drug Approvals

Updated: April 26, 2019

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Drug Recalls

Updated: April 26, 2019

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Drug Shortages

Updated: April 26, 2019

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Gender Differences Seen in Adverse Drug Reactions

FRIDAY, April 26, 2019 (Pharmacist's Briefing) -- The risk for adverse drug reactions (ADRs) may be higher for women, even when accounting for gender differences in drug use, according to a study published online April 2 in the British Journal of Clinical Pharmacology.

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U.S. Death Rate From Drug Poisoning Up for Teens, Young Adults

THURSDAY, April 25, 2019 (Pharmacist's Briefing) -- For adolescents and young adults, the death rate from drug poisoning increased from 2006 to 2015, according to a study published online April 24 in the Journal of Studies on Alcohol and Drugs.

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CDC: Number of U.S. Measles Cases Reaches New High

THURSDAY, April 25, 2019 (Pharmacist's Briefing) -- The number of reported measles cases this year has reached 695, the highest number of reported cases since measles was declared eliminated in the United States in 2000, the U.S. Centers for Disease Control and Prevention announced yesterday.

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Some Children With Asthma Miss Critical Step in Inhaler Use

WEDNESDAY, April 24, 2019 (Pharmacist's Briefing) -- Many children with asthma, especially older children using a spacer with mouthpiece, miss a critical step in inhaler technique, according to a study published online April 8 in the Journal of Hospital Medicine.

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Sleeping Pill Use Tied to Greater Need for BP Meds in Older Adults

WEDNESDAY, April 24, 2019 (Pharmacist's Briefing) -- Consumption of sleeping pills is linked to a subsequent increase in the number of antihypertensive drugs taken among older adults, according to a study published online March 25 in Geriatrics & Gerontology International.

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FDA Approves Pembrolizumab Plus Axitinib for Advanced RCC

TUESDAY, April 23, 2019 (Pharmacist's Briefing) -- The combination of pembrolizumab and axitinib has been approved as a first-line treatment in advanced renal cell carcinoma (RCC), the U.S. Food and Drug Administration announced Friday.

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Risks, Benefits of Long-Term Drug Therapy for Osteoporosis Reviewed

TUESDAY, April 23, 2019 (Pharmacist's Briefing) -- Long-term osteoporosis drug therapy (ODT) reduces fracture risk in women but may increase risk for rare adverse events, and research gaps surround use of long-term drug therapies for osteoporotic fracture prevention, according to a review and position paper published online April 23 in the Annals of Internal Medicine.

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FDA Approves Marketing of First Device to Treat ADHD

MONDAY, April 22, 2019 (Pharmacist's Briefing) -- Marketing has been approved for the first medical device to treat attention-deficit/hyperactivity disorder (ADHD), the U.S. Food and Drug Administration announced Friday.

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Financial Incentives Do Not Boost Use of At-Home CRC Screening Tests

MONDAY, April 22, 2019 (Pharmacist's Briefing) -- Financial incentives do not increase response rates among patients mailed at-home colorectal cancer screening tests, according to a study published online March 22 in JAMA Network Open.

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CDC: United States Set to Break Measles Cases Record

MONDAY, April 22, 2019 (Pharmacist's Briefing) -- Just a few months into the year, the United States is set to break an annual record for the number of measles cases.

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