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Weekly Summary -- April 5, 2019

Friday, Apr. 5, 2019 (Pharmacist's Briefing) -- Here are what Pharmacist's Briefing editors consider the most important developments for the week of April 5, 2019

Black Women in the U.S. Still Missing Out on Heart Care

FRIDAY, April 5, 2019 (Pharmacist's Briefing) -- Older black American women are much less likely to be treated for heart attack and heart disease than white and Hispanic women, researchers say.

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Does Cancer Battle Bring Personal Growth? Yes and No, Survivors Say

FRIDAY, April 5, 2019 (Pharmacist's Briefing) -- Breast cancer survivor Jessica Sidener is adamant that her illness brought real benefits to her life.

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Blacks Live Longer, Not Necessarily Better, With ALS

FRIDAY, April 5, 2019 (Pharmacist's Briefing) -- Black Americans with amyotrophic lateral sclerosis (ALS) tend to live longer than whites with the disease because blacks are more likely to have a procedure called a tracheostomy, a new study shows.

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Simple CPR Doubles Survival Odds

THURSDAY, April 4, 2019 (Pharmacist's Briefing) -- If a few minutes of your time could save a person's life, would you do it?

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Depression Plus HIV Can Turn Deadly

THURSDAY, April 4, 2019 (Pharmacist's Briefing) -- When it coincides with HIV, depression appears associated with an increased risk of death, a new study says.

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High Insulin Costs Come Under Fire on Capitol Hill

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- For many Americans, the cost of lifesaving insulin is simply too high, leading as many as one in four to ration the drug, experts testifying before the House Committee on Energy and Commerce said this week.

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Birth Control Pills May Protect Against Most Serious Ovarian Cancer: Study

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- The protection that birth control pills offer against ovarian cancer is strongest with the most aggressive forms of the disease, a new study says.

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Is That Medication Safe When Breastfeeding?

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- Far too little is known about the safety of medication use during breastfeeding -- and it's time to get some answers, experts say.

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When Using Moisturizers With Sunscreen, Don't Miss Around the Eyes

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- Even though many moisturizers now contain sunscreens, people may not put them on their faces as carefully as they do sunscreen lotions, new research suggests.

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Under-the-Tongue Allergy Pills Replacing Shots for Many

TUESDAY, April 2, 2019 (Pharmacist'sd Briefing) -- Under-the-tongue allergy pills have quickly caught on as a way to treat hay fever and dust mite allergies, a new study finds.

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How HIV Might Influence HPV Vaccination Rates

TUESDAY, April 2, 2019 (Pharmacist'sd Briefing) -- Does being at high risk for HIV mean you're less likely to get the human papillomavirus (HPV) vaccine?

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Coffee on Your Mind? Even Thinking About It 'Arouses' the Brain

MONDAY, April 1, 2019 (Pharmacist's Briefing) -- Need a quick pick-me-up? Just thinking about a cup of joe can give you a mental boost, researchers say.

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Obamacare Is Helping West Virginia Fight the Opioid Crisis

MONDAY, April 1, 2019 (Pharmacist's Briefing) -- New research suggests that the Medicaid expansion the Affordable Care Act set into motion has played a key role in fighting America's opioid epidemic.

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Fish Slime Could Hold Key to Beating 'Superbug' Infections

MONDAY, April 1, 2019 (Pharmacist's Briefing) -- Scientists are looking to an unexpected source in the battle against drug-resistant bacteria: fish slime.

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Second New MS Drug Secures FDA Approval

MONDAY, April 1, 2019 (Pharmacist's Briefing) -- The U.S. Food and Drug Administration has approved another new multiple sclerosis drug -- the second in one week.

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Pot During Pregnancy May Raise Child's Psychosis Risk

MONDAY, April 1, 2019 (Pharmacist's Briefing) -- Children born to mothers who used marijuana during pregnancy may be at increased risk for psychosis, according to a new study.

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One Short, Brisk Walk a Day May Keep Arthritis at Bay

MONDAY, April 1, 2019 (Pharmacist's Briefing) -- Less than 10 minutes a day of brisk walking can help prevent disability in people with arthritis pain in their knee, hip, ankle or foot, researchers report.

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CDC: Prevalence of COPD High Among Some Nonsmokers

FRIDAY, April 5, 2019 (Pharmacist's Briefing) -- The prevalence of chronic obstructive pulmonary disease (COPD) among individuals who have never smoked is high in certain industries and occupations, according to research published in the April 5 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Older Patients With Vision Loss Have Higher Hospital Use, Costs

THURSDAY, April 4, 2019 (Pharmacist's Briefing) -- Hospitalized Medicare beneficiaries with vision loss experience longer mean length of stay, higher readmission rates, and higher costs during hospitalization and postdischarge, according to a study published online April 4 in JAMA Ophthalmology.

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FDA: High Levels of Heavy Metals Found in Kratom Products

THURSDAY, April 4, 2019 (Pharmacist's Briefing) -- Dangerously high levels of heavy metals have been found in dozens of kratom products, the U.S. Food and Drug Administration said Wednesday.

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Most Osteoporosis Guidelines Do Not Discuss Patient Choices

THURSDAY, April 4, 2019 (Pharmacist's Briefing) -- Less than 40 percent of osteoporosis clinical practice guidelines include any mention of patients' beliefs, values, or preferences (BVPs), according to a study published online March 11 in Osteoporosis International.

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FDA Reports Cases of Seizures Among Young Vapers

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- The U.S. Food and Drug Administration warned on Tuesday that there have been reports of teens experiencing seizures after they vape.

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Inferior Facial Coverage Observed With SPF Moisturizer

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- Use of moisturizer with sun protection factors (SPF) is associated with inferior coverage of facial and eyelid regions compared with sunscreen, according to a study published online April 3 in PLOS ONE.

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Many ICU Workers Contaminated With Drug-Resistant Bacteria

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- Improper removal of personal protective equipment (PPE) contaminates health care workers interacting with patients who are on contact precautions for multidrug-resistant organisms (MDROs), according to a study published online March 20 in Infection Control & Hospital Epidemiology.

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Bariatric Embolization Feasible for Treatment of Severe Obesity

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- Bariatric embolization is well tolerated in severely obese adults and is associated with weight loss for up to 12 months, according to a study published online April 2 in Radiology.

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Computer Model Predicts Risk for Ventricular Arrythmia in ARVC

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- A new model can predict the risk for incident ventricular arrhythmias (VAs) in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC), according to a study published online March 27 in the European Heart Journal.

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Population Mortality Affects Long-Term Follow-Up of AlloHCT

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- For older patients undergoing allogeneic hematopoietic cell transplantation (alloHCT), a considerable part of total nonrelapse mortality (NRM) is attributable to population mortality, according to a study recently published in Leukemia.

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Guidelines Address PFO Closure for Secondary Stroke Prevention

TUESDAY, April 2, 2019 (Pharmacist'sd Briefing) -- In a Society for Cardiovascular Angiography and Interventions expert consensus statement published online March 21 in Catheterization and Cardiovascular Interventions, recommendations are presented for patent foramen ovale (PFO) closure for the secondary prevention of recurrent stroke.

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Best Practices Developed for Diagnosing, Managing MINOCA

TUESDAY, April 2, 2019 (Pharmacist'sd Briefing) -- In an American Heart Association scientific statement published online March 27 in Circulation, best practices are presented for diagnostic evaluation and management of myocardial infarction in the absence of obstructive coronary artery disease (MINOCA).

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Sex Hormone Levels May Impact Development of Asthma

TUESDAY, April 2, 2019 (Pharmacist'sd Briefing) -- Sex hormones may impact the risk for asthma, with elevated sex hormone-binding globulin (SHBG) demonstrating a protective effect in females, according to research recently published in Thorax.

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Rates of CPR Before EMS Arrival Increased From 2000 to 2017

MONDAY, April 1, 2019 (Pharmacist's Briefing) -- The rates of compression-only cardiopulmonary resuscitation (CO-CPR) and standard CPR (S-CPR) before arrival of emergency medical services (EMS) have increased and are associated with improved survival over no CPR (NO-CPR), according to a study published online April 1 in Circulation.

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Undiagnosed Gestational Diabetes Ups Risk for Stillbirth

MONDAY, April 1, 2019 (Pharmacist's Briefing) -- Women at risk for gestational diabetes mellitus (GDM) who are not screened or diagnosed are more likely to experience stillbirth than women who undergo screening, according to a study published online March 19 in BJOG, an international journal of obstetrics and gynecology.

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Topical Corticosteroids Associated With Higher Risk for Type 2 Diabetes

FRIDAY, April 5, 2019 (Pharmacist's Briefing) -- There is a positive association between use of topical corticosteroids and incident type 2 diabetes (T2D), according to a study published online April 1 in Diabetes Care.

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No Benefit Seen With Rituximab for Chronic Fatigue Syndrome

FRIDAY, April 5, 2019 (Pharmacist's Briefing) -- In patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), B-cell depletion using several infusions of rituximab over 12 months is not associated with clinical improvement, according to a study published online April 2 in the Annals of Internal Medicine.

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Calcium Intake Tied to Lower Rate of Late AMD

FRIDAY, April 5, 2019 (Pharmacist's Briefing) -- Higher levels of dietary and supplementary calcium intake appear to be associated with a lower incidence of progression to late age-related macular degeneration (AMD), according to a study published online March 21 in JAMA Ophthalmology.

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Histologic Clearance of CIN2/3 Seen With HPV Therapeutic Vaccine

FRIDAY, April 5, 2019 (Pharmacist's Briefing) -- For women with cervical intraepithelial neoplasia (CIN) grade 2 or 3 associated with high-risk human papillomavirus (HPV), an immunotherapeutic tipapkinogen sovacivec (TS) HPV vaccine is effective for achieving histologic resolution, according to a study published online April 4 in Gynecologic Oncology.

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Patient Behaviors Identified That Impact Weight Regain After RYGB

FRIDAY, April 5, 2019 (Pharmacist's Briefing) -- Several patient behaviors are associated with weight regain after Roux-en-Y gastric bypass (RYGB) surgery, including sedentary time, eating fast food, and eating when feeling full, according to a study published online April 4 in the Annals of Surgery.

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Early Hospital Intervention for Diabetes Improves Outcomes

THURSDAY, April 4, 2019 (Pharmacist's Briefing) -- Early intervention for patients with diabetes in the hospital decreases hyperglycemia and hospital-acquired infections, according to a study published online March 28 in Diabetes Care.

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Neoadjuvant Chemotherapy Key to Survival in Pancreatic Cancer

THURSDAY, April 4, 2019 (Pharmacist's Briefing) -- Three factors can predict survival in patients with borderline resectable (BR) or locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC), according to a study published online April 2 in the Annals of Surgery.

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Minerals Not Linked to Multiple Sclerosis Risk in Women

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- Mineral intake seems not to be associated with the risk for multiple sclerosis (MS) among women, according to a study published online April 3 in Neurology.

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Late Preterm Steroid Therapy Found to Be Cost-Effective

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- In women at high risk for late preterm delivery, antenatal treatment with betamethasone is a cost-effective strategy, according to a study published online March 11 in JAMA Pediatrics.

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Beta Interferon Tied to Lower Mortality in Relapsing-Onset MS

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- For patients with relapsing-onset multiple sclerosis, beta interferon treatment is associated with a lower mortality risk, according to a study published online March 18 in Brain.

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Almost Three-Quarters of Allergists Have Prescribed SLIT

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- More than 73 percent of U.S. allergists report prescribing sublingual immunotherapy (SLIT), according to research published online April 1 in the Annals of Allergy, Asthma & Immunology.

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Pembrolizumab Beneficial for Advanced Small Cell Lung Cancer

TUESDAY, April 2, 2019 (Pharmacist'sd Briefing) -- For patients with advanced small cell lung cancer (SCLC), pembrolizumab shows antitumor activity with durable responses, according to a study presented at the annual meeting of the American Association for Cancer Research, held from March 29 to April 3 in Atlanta.

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Dolutegravir Feasible for HIV Tx in Women of Childbearing Age

TUESDAY, April 2, 2019 (Pharmacist'sd Briefing) -- Dolutegravir should be considered for antiretroviral therapy (ART) in treating HIV in women of childbearing potential in resource-limited settings, despite its associated risk for neural tube defects, according to a study published online April 2 in the Annals of Internal Medicine.

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Vitamins, Carotenoids Associated With Lower Risk for Cataract

MONDAY, April 1, 2019 (Pharmacist's Briefing) -- Higher consumption of certain vitamins and carotenoids is associated with a significantly decreased risk for age-related cataract (ARC) in cohort studies, according to a meta-analysis published in the January issue of The American Journal of Clinical Nutrition.

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Liquid Meal Replacements Cut Cardiometabolic Risk Factors

MONDAY, April 1, 2019 (Pharmacist's Briefing) -- Liquid meal replacements in weight loss diets lead to modest reductions in cardiometabolic risk factors for overweight and obese patients with type 2 diabetes, according to a review published online March 28 in Diabetes Care.

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Nasopharyngeal Microbiota Could Help Diagnose Pediatric LRTIs

MONDAY, April 1, 2019 (Pharmacist's Briefing) -- Nasopharyngeal microbiota seem to serve as a valid proxy for lower respiratory tract microbiota in lower respiratory tract infections (LRTIs) among children, according to a study published online March 15 in The Lancet Respiratory Medicine.

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Ibrance Approval Expanded to Include Men With Breast Cancer

FRIDAY, April 5, 2019 (Pharmacist's Briefing) -- U.S. Food and Drug Administration approval of Ibrance (palbociclib) capsules has been widened to include men with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer, the agency said Thursday in a news release.

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Drop Seen in Preinvasive Cervical Disease With HPV Vaccination

THURSDAY, April 4, 2019 (Pharmacist's Briefing) -- Routine vaccination of young girls aged 12 to 13 years with human papillomavirus (HPV) vaccine results in a reduction in preinvasive cervical disease, according to a study published online April 3 in The BMJ.

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Patient-Report Instrument Helps Identify ADEs in Older Adults

THURSDAY, April 4, 2019 (Pharmacist's Briefing) -- A patient-report instrument has good predictive value for identifying adverse drug events (ADEs) in older adults in the community setting, according to a study published in the March/April issue of the Annals of Family Medicine.

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New Plan Limits Out-of-Pocket Costs for Insulin

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- Out-of-pocket costs for insulin could be restricted to $25 a month for people under a drug benefit plan announced Wednesday by Express Scripts.

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HPV Vax Low for Adults at High Risk for HIV Infection

WEDNESDAY, April 3, 2019 (Pharmacist's Briefing) -- Many adults at high risk for HIV infection have low rates of human papillomavirus (HPV) vaccination, according to a study presented at the annual meeting of the American Association for Cancer Research, held from March 29 to April 3 in Atlanta.

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Drug Shortages

Updated: April 3, 2019

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Drug Recalls

Updated: April 3, 2019

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Over-the-Counter Meds Save Health Care System Money

TUESDAY, April 2, 2019 (Pharmacist's Briefing) -- On average, each dollar spent on over-the-counter (OTC) medicines saves the U.S. health care system $7.20, totaling nearly $146 billion in annual savings, according to a report released March 18 by the Consumer Healthcare Products Association (CHPA).

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Guidelines for Asymptomatic Bacteriuria Updated

TUESDAY, April 2, 2019 (Pharmacist'sd Briefing) -- Recommendations have been updated for the management of asymptomatic bacteriuria (ASB); the Infectious Diseases Society of America clinical practice guideline was published online March 21 in Clinical Infectious Diseases.

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Cannabis Products Used Differ for Cancer, Noncancer Patients

MONDAY, April 1, 2019 (Pharmacist's Briefing) -- The forms of medical cannabis used vary for patients with and without cancer, according to a study published online March 25 in the Journal of Palliative Medicine.

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