HEALINE

Weekly Summary -- March 22, 2019

Friday, Mar. 22, 2019 (Pharmacist's Briefing) -- Here are what Pharmacist's Briefing editors consider the most important developments for the week of March 22, 2019

Could the U.S. Mail Deliver Better Colon Cancer Screening Rates?

FRIDAY, March 22, 2019 (Pharmacist's Briefing) -- No one likes to get a colonoscopy, but new research suggests that mailing at-home colon cancer tests to folks who are overdue for their checks might prompt them to get screened.

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Is There a Safer Choice Than Opioids After a C-Section?

FRIDAY, March 22, 2019 (Pharmacist's Briefing) -- Expectant moms often try to plan as many aspects of their upcoming delivery as they can. But one thing they might not consider is what type of pain relief they will choose if they need to have a C-section.

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Extra Calcium Safe for the Aging Eye

FRIDAY, March 22, 2019 (Pharmacist's Briefing) -- To take calcium or not to take calcium, that is still the question.

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What Drives 'Anti-Vaxxer' Parents? It's a Mixed Bag, Study Shows

THURSDAY, March 21, 2019 (Pharmacist's Briefing) -- Anti-vaccination campaigns abound on social media, but the people involved are not necessarily driven by any single motivation, a new study suggests.

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Overdose Deaths From Fentanyl Soaring: Report

THURSDAY, March 21, 2019 (Pharmacist's Briefing) -- The number of Americans dying from overdoses of the powerful narcotic fentanyl rose 12-fold in recent years, health officials reported Thursday.

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Drug Combo Does Double Duty Against Common Skin Lesions, Cancers

THURSDAY, March 21, 2019 (Pharmacist's Briefing) -- Tens of millions of Americans develop sun-linked skin lesions called actinic keratoses, which are tied to later cancer risk.

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Risk of Psychosis Varies With ADHD Meds, But Still Small: Study

WEDNESDAY, March 20, 2019 (Pharmacist's Briefing) -- Stimulant drugs used to treat attention-deficit/hyperactivity disorder (ADHD) carry a small risk of a psychotic episode, but it appears to vary depending on which medication young people use, a new study finds.

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Reworked Nasal Flu Vaccine Looks Good for Kids, Pediatricians' Group Says

WEDNESDAY, March 20, 2019 (Pharmacist's Briefing) -- Good news for kids: Next flu season, you can avoid a painful needle jab and get the nasal vaccine spray instead, according to a leading U.S. pediatricians' group.

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Heart Risks Vary Among Asian-Americans

WEDNESDAY, March 20, 2019 (Pharmacist's Briefing) -- Not all Asian-Americans are equally susceptible to the deadly damage of heart disease and stroke, new research suggests.

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Many With Opioid Addiction Don't Get Meds That Can Help

WEDNESDAY, March 20, 2019 (Pharmacist's Briefing) -- Most people struggling with opioid addiction lack access to FDA-approved medications that can head off withdrawal symptoms and quell their cravings, a new report finds.

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Tighter Blood Pressure Control May Prevent Brain Lesions

WEDNESDAY, March 20, 2019 (Pharmacist's Briefing) -- Reducing high blood pressure in the elderly appears to lower their odds of developing brain lesions, a new study finds.

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Hormonal Therapy for Prostate Cancer Might Raise Depression Risk

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- Hormonal treatment can help control prostate cancer but may increase a man's risk of depression, a new study by Danish researchers suggests.

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Stopping Aspirin 3 Months After Stent Is Safe, Study Finds

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- Heart patients who get a stent to prop open a blocked artery are typically put on a powerful anti-clotting drug and aspirin for a full year after their procedure.

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Can Some Children Outgrow Autism?

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- Some toddlers thought to have mild autism "outgrow" the diagnosis, but most continue to struggle with language and behavior, new research suggests.

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Prescription Fish Oil Pill Lowers Heart Attack Risk in Those Already on Statins

MONDAY, March 18, 2019 (Pharmacist's Briefing) -- Patients who have high triglycerides and take cholesterol-lowering statins to lower their risk for heart attack or stroke can cut that risk by another 30 percent by adding a high-dose omega-3 fatty acid pill, investigators report.

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Robust Evidence Lacking for Many Cardiovascular Guidelines

THURSDAY, March 21, 2019 (Pharmacist's Briefing) -- Only a small proportion of recommendations in major cardiovascular society guidelines are supported by evidence from multiple randomized controlled trials (RCTs) or a single large RCT, according to a study published in the March 19 issue of the Journal of the American Medical Association. This cardiovascular medicine theme issue was released early to coincide with the annual meeting of the American College of Cardiology, held from March 16 to 18 in New Orleans.

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Patients With Diabetes at Increased Risk for Sleep Apnea

WEDNESDAY, March 20, 2019 (Pharmacist's Briefing) -- Patients with type 2 diabetes are at increased risk for developing obstructive sleep apnea (OSA), independent of other factors, according to a study published online March 12 in Diabetes Care.

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Healthy Food Rx Could Be Cost-Effective for Medicare, Medicaid

WEDNESDAY, March 20, 2019 (Pharmacist's Briefing) -- Economic incentives for healthier foods through Medicare and Medicaid could generate substantial health gains and be highly cost-effective, according to a study published online March 19 in PLOS Medicine.

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FDA: First Treatment Approved Specifically for Postpartum Depression

WEDNESDAY, March 20, 2019 (Pharmacist's Briefing) -- Zulresso (brexanolone) injection has been approved for intravenous (IV) use in the treatment of postpartum depression (PPD) in adult women, marking the first drug approved specifically for PPD, the U.S. Food and Drug Administration announced yesterday.

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Recommendations Issued for HSCT in Multiple Myeloma

WEDNESDAY, March 20, 2019 (Pharmacist's Briefing) -- A consensus statement for the use of hematopoietic stem cell transplantation (HSCT) in the treatment of multiple myeloma (MM) has been developed by Mayo Clinic physicians; the recommendations were published in the March issue of Bone Marrow Transplantation.

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CDC: New HIV Transmission Often From Those Unaware of Infection

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- Most new HIV transmissions are from people who do not know they have HIV infection or are aware of infection but are not receiving care, according to research published in the March 18 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Light Physical Activity Tied to Lower CHD, CVD Risk in Women

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- Light physical activity (PA) is associated with reductions in coronary heart disease (CHD) and cardiovascular disease (CVD) among older women, according to a study published online March 15 in JAMA Network Open.

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Favorable Outcomes Seen in Long Term for ALLR3 Trial

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- For children with B-cell precursor acute lymphoblastic leukemia with late bone marrow relapse, risk stratification by minimal residual disease seems to be an effective strategy for treatment, according to a study recently published in The Lancet Haematology.

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In Utero Ultrafine Particle Exposure Tied to Asthma in Offspring

MONDAY, March 18, 2019 (Pharmacist's Briefing) -- Exposure to ultrafine particles (UFPs; <0.1 μm) during the second trimester in utero is linked to the subsequent onset of asthma in children, according to a study published online Feb. 20 in the American Journal of Respiratory and Critical Care Medicine.

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Active Interventions Generally Helpful for Urinary Incontinence

MONDAY, March 18, 2019 (Pharmacist's Briefing) -- Most active interventions are more likely than no treatment to improve outcomes for women with either stress or urgency urinary incontinence (UI), according to a review published online March 19 in the Annals of Internal Medicine.

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Three Factors Predict Psych Events With Drugs for Smoking Cessation

THURSDAY, March 21, 2019 (Pharmacist's Briefing) -- Three factors predict clinically significant neuropsychiatric adverse events (NPSAEs) in smokers with or without mental health conditions who use cessation pharmacotherapy, according to a study published online March 7 in the Journal of General Internal Medicine.

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Antibiotics, PPIs Tied to Higher C. Diff Risk in Hospitalized Children

THURSDAY, March 21, 2019 (Pharmacist's Briefing) -- Previous antibiotic exposure and use of proton pump inhibitors (PPIs) may be risk factors for Clostridioides (formerly Clostridium) difficile infection (CDI) in hospitalized pediatric patients, according to a review published online March 7 in Infection Control & Hospital Epidemiology.

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In Youth With ADHD, New-Onset Psychosis Up With Amphetamines

THURSDAY, March 21, 2019 (Pharmacist's Briefing) -- For adolescents and young adults with attention-deficit/hyperactivity disorder (ADHD), new-onset psychosis occurs more often with amphetamine use versus methylphenidate use, according to a study published in the March 21 issue of the New England Journal of Medicine.

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Daily Cannabis Use May Up Risk for Developing Psychotic Disorder

WEDNESDAY, March 20, 2019 (Pharmacist's Briefing) -- Cannabis use is associated with increased odds of psychotic disorder, according to a study published online March 19 in The Lancet Psychiatry.

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Antiepileptic Drugs Not Tied to Dementia Risk

WEDNESDAY, March 20, 2019 (Pharmacist's Briefing) -- Antiepileptic drug (AED) use is not significantly associated with dementia risk in patients in Germany, according to a study published online March 12 in the Journal of Alzheimer's Disease.

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FDA OKs Tecentriq for Extensive-Stage Small Cell Lung Cancer

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- Tecentriq (atezolizumab) has been approved by the U.S. Food and Drug Administration to treat adults with extensive-stage small cell lung cancer.

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Analgesics in Pregnancy Do Not Seem to Cause Offspring Asthma

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- Analgesics taken during pregnancy, including opioids, antimigraine drugs, and paracetamol, do not appear to cause asthma, according to a study published online March 17 in the European Respiratory Journal.

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Testosterone Replacement Slows Prostate Cancer Recurrence

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- For patients with localized prostate cancer, testosterone replacement therapy (TRT) slows recurrence, according to a study presented at the annual meeting of the European Association of Urology, held from March 15 to 19 in Barcelona, Spain.

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Favorable Outcomes Seen in Long Term for ALLR3 Trial

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- For children with B-cell precursor acute lymphoblastic leukemia with late bone marrow relapse, risk stratification by minimal residual disease seems to be an effective strategy for treatment, according to a study recently published in The Lancet Haematology.

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Dietary Cholesterol Ups Cardiovascular Disease Risk

MONDAY, March 18, 2019 (Pharmacist's Briefing) -- Higher consumption of dietary cholesterol, including eggs, is significantly associated with a higher risk for incident cardiovascular disease (CVD) and all-cause mortality, according to a study published in the March 19 issue of the Journal of the American Medical Association. This cardiovascular medicine theme issue was released early to coincide with the annual meeting of the American College of Cardiology, held from March 16 to 18 in New Orleans.

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Antibacterial Envelope Can Reduce CIED Infections

MONDAY, March 18, 2019 (Pharmacist's Briefing) -- An antibacterial envelope can reduce the incidence of major cardiac implantable electronic device (CIED) infections, according to a study published online March 17 in the New England Journal of Medicine to coincide with the annual meeting of the American College of Cardiology, held from March 16 to 18 in New Orleans.

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Recent Increase Reported in Drug Overdose Deaths Involving Fentanyl

THURSDAY, March 21, 2019 (Pharmacist's Briefing) -- From 2011 to 2016, there was an increase in drug overdose deaths involving fentanyl, according to the March 21 National Vital Statistics Reports, a publication from the U.S. Centers for Disease Control and Prevention.

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Cannabidiol Products Now Available at Hundreds of CVS Stores

THURSDAY, March 21, 2019 (Pharmacist's Briefing) -- Creams, sprays, and lotions infused with the nonintoxicating hemp component cannabidiol (CBD) are now being sold at more than 800 CVS stores in eight states.

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DG/health NATURALS Cough Syrup + Mucus for Infants Recalled

THURSDAY, March 21, 2019 (Pharmacist's Briefing) -- One lot of DG/health NATURALS baby Cough Syrup + Mucus is being recalled due to possible contamination with potentially harmful bacteria, says maker Kingston Pharma, LLC.

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Statins Tied to Insulin Resistance, Higher Serum Fasting Insulin

THURSDAY, March 21, 2019 (Pharmacist's Briefing) -- Individuals using statins may be at higher risk for hyperglycemia, insulin resistance, and eventually type 2 diabetes, according to a study published online March 5 in the British Journal of Clinical Pharmacology.

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Practices for Reducing COPD Hospital Readmissions Explored

WEDNESDAY, March 20, 2019 (Pharmacist's Briefing) -- Communication, implementation of guidelines, and improved identification of risk factors may help reduce chronic obstructive pulmonary disease (COPD) hospital readmissions, according to a report published in the February issue of the Annals of the American Thoracic Society.

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FDA Warns Homeopathic Company About Illegal Product Claims

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- Nutra Pharma Corp. has been warned about illegal marketing of unapproved homeopathic products with claims that they can treat addiction and chronic pain from serious conditions such as cancer, diabetes, shingles, and fibromyalgia, the U.S. Food and Drug Administration says.

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Bluetooth Technology Enables Insulin Adherence Monitoring

TUESDAY, March 19, 2019 (Pharmacist's Briefing) -- Adherence to timing and dosing of insulin injections can be objectively measured using Bluetooth-enabled pen caps, according to a study published online March 12 in Diabetes Care.

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Average of 8.8 Inactive Ingredients Found in Oral Medications

MONDAY, March 18, 2019 (Pharmacist's Briefing) -- Oral forms of medications contain an average of 8.8 inactive ingredients, many of which could cause adverse reactions, according to a perspective piece published in the March 13 issue of Science Translational Medicine.

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FDA Issues Update on Mortality Risk With Paclitaxel-Coated Products

MONDAY, March 18, 2019 (Pharmacist's Briefing) -- A preliminary analysis has revealed a "potentially concerning signal" of increased long-term mortality risk with paclitaxel-coated products indicated for peripheral arterial disease (PAD), according to a March 15 update from the U.S. Food and Drug Administration.

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Adherence to Statins Low Among Patients With ASCVD

MONDAY, March 18, 2019 (Pharmacist's Briefing) -- Few patients are optimally adherent to statins, although adherence is associated with a reduced risk for major adverse cardiovascular events (MACE), according to a study presented at the annual meeting of the American College of Cardiology, held from March 16 to 18 in New Orleans.

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