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Weekly Summary -- March 8, 2019

Friday, Mar. 8, 2019 (Pharmacist's Briefing) -- Here are what Pharmacist's Briefing editors consider the most important developments for the week of March 8, 2019

Beware of Drowsy Driving as Daylight Saving Time Begins

FRIDAY, March 8, 2019 (Pharmacist's Briefing) -- The switch to Daylight Saving Time can increase the risk of driver fatigue and crashes, but there are a number of ways to reduce the danger, an expert says.

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Hormone Therapy Linked to Slight Rise in Alzheimer's Risk

THURSDAY, March 7, 2019 (Pharmacist's Briefing) -- Many women turn to hormone therapy to ease some of the more troubling symptoms of menopause, such as hot flashes and night sweats.

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Study Disputes Pregnancy Link to MS Relapses

THURSDAY, March 7, 2019 (Pharmacist's Briefing) -- A new study challenges the long-held belief that multiple sclerosis (MS) can flare up right after pregnancy in women with the relapsing-remitting form of the disease.

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High Testosterone Levels Are Bad News for the Heart

THURSDAY, March 7, 2019 (Pharmacist's Briefing) -- High testosterone levels can drastically increase a man's risk of heart failure and stroke-causing blood clots, a new study reports.

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Even a Drink a Day Might Raise Your Blood Pressure

THURSDAY, March 7, 2019 (Pharmacist's Briefing) -- Prior studies have suggested that a little drinking might help the heart. But rigorous new research suggests the opposite, finding that even a drink or two per day is tied to rising blood pressure.

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Which Misused Prescription Meds Send Americans to the ER?

WEDNESDAY, March 6, 2019 (Pharmacist's Briefing) -- Most folks treated in a U.S. emergency room for misuse of prescription medications get into trouble because they mix different substances, a new study reports.

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FDA Poised to Approve Ketamine-Like Drug to Ease Depression

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- The U.S. Food and Drug Administration could give its approval this week to esketamine -- a relative of the "club drug" and anesthetic ketamine -- against severe depression.

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Too Few Seniors Are Getting Their Memory Tested

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- Most seniors expect their doctor to recommend testing of thinking and memory when it's needed.

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Hot Cocoa May Ease the Fatigue of MS

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- Fatigue can plague many people with multiple sclerosis (MS). But a small new study suggests a soothing cup of hot cocoa may bring some relief.

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Exercise Might Slow Colon Cancer's Advance

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- Exercise has countless benefits, even in small doses. And new research suggests the payoffs might extend to colon cancer patients.

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Sleep Apnea May Be Linked With Alzheimer's Marker

SUNDAY, March 3, 2019 (Pharmacist's Briefing) -- Millions of Americans are left drowsy each day by sleep apnea, and new research suggests it might also raise their odds for Alzheimer's disease.

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Raspberries May Aid Glucose Control With Prediabetes

THURSDAY, March 7, 2019 (Pharmacist's Briefing) -- Eating red raspberries may help with glucose control in people with prediabetes, according to a small study published online Feb. 14 in Obesity.

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High-Quality, Plant-Based Diet Tied to Lower Risk for CVD Mortality

THURSDAY, March 7, 2019 (Pharmacist's Briefing) -- Increasing consumption of high-quality, plant-based foods decreases the risk for death from cardiovascular disease (CVD), according to a study presented at the American Heart Association Epidemiology and Prevention/Lifestyle and Cardiometabolic Health 2019 Scientific Sessions, held from March 5 to 8 in Houston.

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AAN: Sweetened Drinks Linked to More Severe Disability in MS

WEDNESDAY, March 6, 2019 (Pharmacist's Briefing) -- Sugar-sweetened beverage consumption is associated with an increased risk for severe versus mild-to-moderate disability among individuals with multiple sclerosis (MS), according to a study scheduled for presentation at the upcoming annual meeting of the American Academy of Neurology, to be held from May 4 to 10 in Philadelphia.

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Behavioral Intervention Ups Physical Activity in T2DM

WEDNESDAY, March 6, 2019 (Pharmacist's Briefing) -- A behavioral intervention results in a sustained increase in physical activity and decrease in sedentary time among patients with type 2 diabetes, according to a study published in the March 5 issue of the Journal of the American Medical Association.

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Studies Look at Ways to Reduce Depressive Episodes in Obese

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- For overweight adults with depression, daily multinutrient supplements and individual or group therapy sessions do not reduce major depressive disorder (MDD) episodes over one year, but an integrated intervention appears to be beneficial, according to two studies published in the March 5 issue of the Journal of the American Medical Association.

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AASM Releases New Sleep Apnea Treatment Guideline

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- A new guideline, published Feb. 15 in the Journal of Clinical Sleep Medicine, establishes clinical practice recommendations for positive airway pressure (PAP) treatment of obstructive sleep apnea (OSA) in adults.

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Children With Atopic Dermatitis Have Worse Sleep Quality

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- Children with atopic dermatitis (AD) have worse sleep quality, according to a study published online March 4 in JAMA Pediatrics.

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Higher Intake of Whole Grains May Lower Risk for Liver Cancer

MONDAY, March 4, 2019 (Pharmacist's Briefing) -- Higher intake of whole grains may be associated with a lower risk for hepatocellular carcinoma (HCC) among U.S. adults, according to a study published online Feb. 21 in JAMA Oncology.

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Hypertensive Disorders of Pregnancy Tied to Stroke Risk

MONDAY, March 4, 2019 (Pharmacist's Briefing) -- Women with a history of hypertensive disorders of pregnancy (HDP) have a greater long-term risk for stroke that is reduced by aspirin use, according to a study recently published in Neurology.

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Pneumococcal Vaccination at Age 50 Prevents the Most Disease

MONDAY, March 4, 2019 (Pharmacist's Briefing) -- Recommending pneumococcal vaccination for all 50-year-olds prevents the most disease in underserved minorities and the general population, but the cost exceeds $250,000 per quality-adjusted life-year (QALY) gained, according to a study published online March 4 in Vaccine.

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AAN: Sleep Apnea Tied to Higher Cortical Tau Levels in Seniors

MONDAY, March 4, 2019 (Pharmacist's Briefing) -- Older adults who are witnessed to have sleep apnea have increased accumulations of tau in the entorhinal cortex (ERC), according to a study scheduled for presentation at the upcoming annual meeting of the American Academy of Neurology, to be held from May 4 to 10 in Philadelphia.

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Probiotic Sanitation Cuts Antimicrobial Resistance in Hospitals

THURSDAY, March 7, 2019 (Pharmacist's Briefing) -- An environmental intervention of probiotic sanitation can effectively alter hospital microbiota, helping to limit the spread of antimicrobial resistance (AMR) in health care-associated infections (HAIs), according to a study published online Feb. 27 in Infection and Drug Resistance.

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Hospital-Onset MRSA Decreased From 2002 to 2015

WEDNESDAY, March 6, 2019 (Pharmacist's Briefing) -- Staphylococcus aureus infections are still a concern in the United States, despite a decline seen in hospital-onset methicillin-resistant S. aureus (MRSA) infections since 2005, according to two reports published in the March 5 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Few Seniors Receive Regular Brief Cognitive Assessments

WEDNESDAY, March 6, 2019 (Pharmacist's Briefing) -- Only 16 percent of seniors receive regular cognitive assessments, according to the Alzheimer's Disease Facts and Figures report published March 5.

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Fluorouracil Cream Best Choice for Tx of Actinic Keratosis Lesions

WEDNESDAY, March 6, 2019 (Pharmacist's Briefing) -- For patients with multiple actinic keratosis lesions on the head, 5 percent fluorouracil cream is the most effective treatment, according to a study published in the March 7 issue of the New England Journal of Medicine.

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Program in Peds Rheumatology Clinic Ups Education on Teratogenic Rx

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- A series of interventions introduced through a quality improvement project can increase the frequency of both teratogen education and urine pregnancy screening in patients taking teratogenic medications for rheumatic disease, according to a study published online March 5 in Pediatrics.

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Recommendations Developed for Ulcerative Colitis Management

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- Recommendations have been developed for management of adults with ulcerative colitis (UC); the American College of Gastroenterology clinical guideline was published online Feb. 21 in the American Journal of Gastroenterology.

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Problems Identified With Gaps in EHR Functionality in Morning Rounds

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- There is a considerable amount of variability in the ways in which electronic health records (EHRs) are used during morning rounds, resulting in extensive use of workarounds and problems with team communication, according to a study published online Feb. 25 in PLOS ONE.

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Low-Dose Aspirin Does Not Cut Death From Prostate Cancer

MONDAY, March 4, 2019 (Pharmacist's Briefing) -- Low-dose aspirin use does not appear to reduce the overall risk for prostate cancer death, according to a study published online March 5 in the Annals of Internal Medicine.

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Oscillometric Devices Offer More Accurate Way to Measure BP

MONDAY, March 4, 2019 (Pharmacist's Briefing) -- Oscillometric devices allow accurate office blood pressure (BP) measurement while reducing human errors associated with the auscultatory approach, according to a scientific statement published online March 4 in Hypertension.

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Intraoperative Methylprednisolone During Bypass Not Renal Protective

MONDAY, March 4, 2019 (Pharmacist's Briefing) -- For patients undergoing cardiac surgery with a cardiopulmonary bypass pump, administration of intravenous methylprednisolone does not reduce the risk for acute kidney injury, according to a study published online March 4 in CMAJ, the journal of the Canadian Medical Association.

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Pneumococcal Vaccination at Age 50 Prevents the Most Disease

MONDAY, March 4, 2019 (Pharmacist's Briefing) -- Recommending pneumococcal vaccination for all 50-year-olds prevents the most disease in underserved minorities and the general population, but the cost exceeds $250,000 per quality-adjusted life-year (QALY) gained, according to a study published online March 4 in Vaccine.

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Making Sense of the Recent Blood Pressure Drug Recalls

FRIDAY, March 8, 2019 (Pharmacist's Briefing) -- People taking blood pressure medications have faced a frightening and bewildering series of pharmaceutical recalls in recent months, as trace amounts of cancer-causing chemicals have been discovered in individual batches of drugs.

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Persistent, Prolonged Opioid Use Occurs After Plastic Surgery

THURSDAY, March 7, 2019 (Pharmacist's Briefing) -- Persistent and prolonged opioid use occur after plastic and reconstructive surgical procedures, according to a study published online March 7 in JAMA Facial Plastic Surgery.

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About 360,000 ED Visits Were for Nonmedical Drug Abuse in 2016

WEDNESDAY, March 6, 2019 (Pharmacist's Briefing) -- In 2016, there were an estimated 358,247 emergency department visits for harms from nonmedical use of pharmaceuticals, according to a study published online March 6 in the American Journal of Preventive Medicine.

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FDA Approves Ketamine-Like Drug for Severe Depression

WEDNESDAY, March 6, 2019 (Pharmacist's Briefing) -- The U.S. Food and Drug Administration on Tuesday approved the nasal spray medication esketamine -- a relative of the club drug and anesthetic ketamine -- for use against severe depression. Sold as Spravato, the fast-acting drug becomes the first new type of medicine approved in years against an illness that affects millions of Americans.

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FDA Commissioner Dr. Scott Gottlieb Resigns

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- In what probably came as a surprise to many, U.S. Food and Drug Administration Commissioner Scott Gottlieb, M.D., announced his resignation on Tuesday. Gottlieb is leaving the FDA because he wants to spend more time with his wife and three young daughters -- twins aged 9 and a 5-year-old -- one official said. He currently commutes each week from the family home in Connecticut to his Washington, D.C., office.

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AAP: Social Media Companies Must Curb Spread of Vaccine Myths

TUESDAY, March 5, 2019 (Pharmacist's Briefing) -- Google, Facebook, and Pinterest need to take more action against the growing threat to children posed by online misinformation about vaccines, the American Academy of Pediatrics said in a letter sent to the social media companies.

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MMR Not Linked to Autism in Danish Cohort Study

MONDAY, March 4, 2019 (Pharmacist's Briefing) -- Measles, mumps, rubella (MMR) vaccination is not associated with an increased risk for autism, including in children with autism risk factors, according to a study published online March 5 in the Annals of Internal Medicine.

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Eli Lilly to Sell Cheaper Version of Insulin Drug

MONDAY, March 4, 2019 (Pharmacist's Briefing) -- A cheaper version of Eli Lilly's most popular insulin drug, Humalog, is being introduced by the drug maker.

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Multidimensional Approach Cuts Unneeded Drug-Drug Interaction Alerts

MONDAY, March 4, 2019 (Pharmacist's Briefing) -- An iterative, multidimensional quality improvement (QI) effort can reduce interruptive drug-drug interaction (DDI) alerts, according to a study published in the March issue of Pediatrics.

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